2. Apoptosis Metabolic Enzyme/Protease
  3. Ferroptosis Glutathione Peroxidase
  4. Ferroptosis inducer-10

Ferroptosis inducer-10 是一种铁死亡 (ferroptosis) 诱导剂。Ferroptosis inducer-10 能抑制 A549 细胞的生长，其 IC50 值为 0.76 μM。Ferroptosis inducer-10 可消耗谷胱甘肽 (GSH)，升高活性氧 (ROS) 和丙二醛 (MDA)，并下调谷胱甘肽过氧化物酶 4 (GPX4) 的表达。Ferroptosis inducer-10 能诱导细胞停滞于 G2/M 期并抑制迁移。Ferroptosis inducer-10 可用于癌症研究，如非小细胞肺癌。

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Ferroptosis inducer-10

Ferroptosis inducer-10 Chemical Structure

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Ferroptosis inducer-10 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Ferroptosis inducer-10 is a ferroptosis inducer. Ferroptosis inducer-10 can inhibit A549 cells growth with an IC50 of 0.76 μM. Ferroptosis inducer-10 can deplete GSH, elevate ROS and MDA, and downregulate GPX4 expression. Ferroptosis inducer-10 can induce cell G2/M phase and inhibit migration. Ferroptosis inducer-10 can be used for the research of cancer, such as non-small lung cancer[1].

IC50 & Target[1]

GPX4

 

体外研究
(In Vitro)

Ferroptosis inducer-10 (Compound I-21) 在 A549、HT-1080、MCF-7、Panc-02 和 PC-3 细胞中表现出抗增殖活性，其 IC50 值分别为 0.76、1.03、4.86、3.41 和 1.34 μM[1]。
Ferroptosis inducer-10 对人脐静脉内皮细胞无明显毒性 (IC50 = 24.66 μM)[1]。
Ferroptosis inducer-10 (0.5-4 μM) 可增加 A549 细胞中活性氧和丙二醛的水平，并降低谷胱甘肽（GSH）的水平[1]。
Ferroptosis inducer-10 (0.5-4 μM, 12 h) 会使 A549 细胞中的 Fe2+ 水平升高[1]。
Ferroptosis inducer-10 (0.5-4 μM) 会导致 A549 细胞皱缩和碎裂[1]。
Ferroptosis inducer-10 (0.5-4 μM) 可下调 A549 细胞中谷胱甘肽过氧化物酶 4 的水平[1]。
Ferroptosis inducer-10 (1-4 μM, 24 h) 可诱导 A549 细胞发生 G2/M 期阻滞[1]。
Ferroptosis inducer-10 (0.5-2 μM, 7 days) 可减少 A549 细胞的集落形成[1]。
Ferroptosis inducer-10 (0.5-4 μM, 48 h) 可抑制 A549 细胞的迁移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-10 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0.5, 1 and 2 μM
Incubation Time: 12 and 24 h
Result: Downregulated GPX4 levels.

Cell Cycle Analysis[1]

Cell Line: A549 cells
Concentration: 1, 2 and 4 μM
Incubation Time: 24 h
Result: Increased the G2/M phase percentage.
Decreased S and G1 proportion.
分子量

302.33

Formula

C19H14N2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ferroptosis inducer-10 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis inducer-10Ferroptosis inducer10Ferroptosis inducer 10FerroptosisGlutathione PeroxidaseGSHROSMDAGPX4A549HT-1080MCF-7Panc-02PC-3Inhibitorinhibitorinhibit

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