2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker DNA/RNA Synthesis
  4. FK 973

FK 973 是一种二氢苯并噁嗪类的抗癌剂。FK 973 选择性抑制 DNA 合成，且能通过胞质激活形成 DNA 交联。FK 973 对多种动物肿瘤模型和人肿瘤异种移植具有显著抗肿瘤活性，且骨髓抑制作用较弱。FK 973 对神经肿瘤细胞具有敏感性。FK 973 可用于 DNA 靶向抗肿瘤研究。

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FK 973

FK 973 Chemical Structure

CAS No. : 114580-45-9

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FK 973 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FK 973 is a dihydrobenzoxazine anticancer agent. FK 973 selectively inhibits DNA synthesis and can form DNA cross-links through cytoplasmic activation. FK 973 exhibits significant antitumor activity in various animal tumor models and human tumor xenografts, with relatively weak myelosuppressive effects. FK 973 is sensitive to neural tumor cells. FK 973 can be used for DNA-targeted antitumor research[1][2].

体外研究
(In Vitro)

FK 973 (48 小时) 可抑制多种癌细胞的生长，包括人胶质母细胞瘤 (ONS-6、12、23 和 ONS-12/ACNU)、人髓母细胞瘤 (ONS-76、81)、人神经母细胞瘤 (ST)、鼠胶质母细胞瘤 (RSV-M 胶质瘤) 和 L1210 细胞，其 IC50 值为 0.06-5 μg/mL[1][2]。
FK 973 (0-30 μM，1 小时) 可在 L1210 细胞中形成 DNA-DNA 链间交联和 DNA-蛋白质交联，而不会导致 DNA 单链断裂[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FK 973 相关抗体:
体内研究
(In Vivo)

FK 973 (鞘内注射) 在脑膜胶质瘤病模型中显著延长小鼠生存期[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

447.40

Formula

C20H21N3O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FK 973 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FK 973114580-45-9FK973FK-973DNA Alkylator/CrosslinkerDNA/RNA SynthesisAntitumor antibioticdihydrobenzoxazine derivativeDNA interstrand cross-linksDNA-protein cross-linksInhibitorinhibitorinhibit

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