1. Apoptosis
    Immunology/Inflammation
    Autophagy
    Epigenetics
    PROTAC
  2. FKBP
    Epigenetic Reader Domain
    PROTAC
  3. FKBP12 PROTAC dTAG-7

FKBP12 PROTAC dTAG-7 (Synonyms: dTAG-7)

目录号: HY-123941
产品使用指南

FKBP12 PROTAC dTAG-7 (dTAG-7) 是一种双功能降解剂。FKBP12 PROTAC dTAG-7 (dTAG-7) 既是一种 FKBP12F36V 的降解剂,又是一种选择性的 BET BRD4 降解剂,FKBP12 PROTAC dTAG-7 (dTAG-7) 通过将 BET 溴结构域桥接至 E3 泛素连接酶 (cereblon; CRBN) 而形成降解剂。

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FKBP12 PROTAC dTAG-7 Chemical Structure

FKBP12 PROTAC dTAG-7 Chemical Structure

CAS No. : 2064175-32-0

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Description

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. FKBP12 PROTAC dTAG-7 (dTAG-7) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-7 (dTAG-7) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN[1].

IC50 & Target[1]

FKBP12(F36V)

 

BRD4

 

PROTAC

 

Molecular Weight

1210.32

Formula

C₆₃H₇₉N₅O₁₉

CAS No.

2064175-32-0

SMILES

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCOCCOCCOCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
FKBP12 PROTAC dTAG-7
目录号:
HY-123941
需求量:

FKBP12 PROTAC dTAG-7

Cat. No.: HY-123941