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  5. 蛋白降解靶向嵌合体化合物库
蛋白降解靶向嵌合体化合物库 - PROTAC Library

Cat. No.: HY-L151

蛋白降解靶向嵌合体 (PROTACs; Proteolysis-targeting chimeras) 是一类利用泛素-蛋白酶体系统 (UPS) 将靶蛋白泛素化并降解的分子。PROTACs 分子由两个被一个连接体连接的配体组成。PROTACs 分子与靶蛋白之间一对一的相互作用关系决定了 PROTACs 分子的作用高效性,使其成为靶向蛋白降解 (TPD) 治疗的潜力分子。

MCE 提供独特的 225 PROTACs 集合,具有强大的筛选能力,能够有效地降解靶蛋白。MCE PROTAC 库是信号通路研究、蛋白质降解治疗研究、药物发现和药物再利用等的有效工具。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Widely used in the research focus areas such as Cancer, Stem Cell, Neuronal Signaling, Immunity, and more.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 225 PROTACs supplied as pre-dissolved Solutions or Solid.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    PROTAC Library
    目录号:
    HY-L151
    需求量: