1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. GABA Receptor
  3. GABAA receptor agent 5

GABAA receptor agent 5 (compound 018) 是一种有效的 γ-GABAAR 拮抗剂,Ki 为 0.020 µM。GABAA receptor agent 5 显示 γ-GABAAR 拮抗剂活性,细胞膜通透性低。

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GABAA receptor agent 5 Chemical Structure

GABAA receptor agent 5 Chemical Structure

CAS No. : 1808389-92-5

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GABAA receptor agent 5 (compound 018) is a potent γ-GABAAR antagonist with an Ki of 0.020 µM. GABAA receptor agent 5 shows γ-GABAAR antagonist activity with low cellular membrane permeability[1].

体外研究
(In Vitro)

GABAA receptor agent 5 (compound 018) shows antagonist activity with IC50s of 0.24, 0.088, 0.068, 0.33, 0.79, 0.32, 0.079, 0.051 µM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, α5β2γ2 subtypes, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

383.51

Formula

C21H25N3O2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GABAA receptor agent 5
目录号:
HY-145257
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