2. Gene
  3. Nsd2 - nuclear receptor binding SET domain protein 2 Gene

Nsd2 - nuclear receptor binding SET domain protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MMSET; Whsc1; Whsc1l; mKIAA1090; 5830445G22Rik; 9430010A17Rik; C130020C13Rik; D030027O06Rik; D930023B08Rik

基因 ID: 107823 | 基因类型: protein coding

关于 Nsd2

功能概要

Enables chromatin binding activity; histone-lysine N-methyltransferase activity; and sequence-specific DNA binding activity. Acts upstream of or within several processes, including cardiac septum morphogenesis; histone lysine methylation; and regulation of nucleobase-containing compound metabolic process. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Human ortholog(s) of this gene implicated in Wolf-Hirschhorn syndrome. Orthologous to human NSD2 (nuclear receptor binding SET domain protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Nsd2 基因产物(3)

mRNA Protein Name
NM_001081102.2 NP_001074571.2 histone-lysine N-methyltransferase NSD2 isoform 1
NM_001177884.1 NP_001171355.1 histone-lysine N-methyltransferase NSD2 isoform 3
NM_175231.2 NP_780440.2 histone-lysine N-methyltransferase NSD2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
19483677 MGI
enables histone H3K36 trimethyltransferase activity IDA
IDA: 通过直接分析推断
19483677 MGI
enables histone methyltransferase activity IDA
IDA: 通过直接分析推断
19483677 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19483677 MGI
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23241889 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within atrial septum primum morphogenesis IMP
IMP: 通过突变表型推断
19483677 MGI
acts upstream of or within atrial septum secundum morphogenesis IMP
IMP: 通过突变表型推断
19483677 MGI
acts upstream of or within bone development IMP
IMP: 通过突变表型推断
19483677 MGI
acts upstream of or within membranous septum morphogenesis IMP
IMP: 通过突变表型推断
19483677 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
19483677 MGI
acts upstream of or within positive regulation of isotype switching to IgA isotypes IMP
IMP: 通过突变表型推断
23241889 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
23241889 MGI
acts upstream of or within regulation of double-strand break repair via nonhomologous end joining IMP
IMP: 通过突变表型推断
23241889 MGI
acts upstream of or within regulation of establishment of protein localization IMP
IMP: 通过突变表型推断
23241889 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
19483677 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase NSD2

IL5 promoter REII region-binding protein

multiple myeloma SET domain-containing protein

nuclear SET domain-containing protein 2

probable histone-lysine N-methyltransferase NSD2

trithorax/ash1-related protein 5

wolf-Hirschhorn syndrome candidate 1 pro

相关产品

Pre-clinical Phase
生物活性分子 (36)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100034 NSC 663284 Inhibitor 99.29% 否
HY-114208A BI-9321 trihydrochloride Antagonist 99.83% 否
HY-157251 UNC8153 TFA Degrader 99.92% 否
HY-154812 Gintemetostat Inhibitor 99.81% 否
HY-161574 LLC0424 Inhibitor 98.42% 否
HY-151101 MS159 99.38% 否
HY-145103 UNC6934 Chemical 99.15% 否
HY-138283 MR837 Inhibitor 99.82% 否
HY-114340 LEM-14 98.02% 否
HY-162308 NSD-IN-3 98.0% 否
HY-171119 NSD2-PWWP1-IN-1 Inhibitor 98.72% 否
HY-15647 BRD9539 Inhibitor 99.73% 否
HY-161575 NSD2 ligand 1 99.76% 否
HY-171121 NSD2-PWWP1-IN-3 Inhibitor 99.63% 否
HY-147914 NSD2-IN-1 Inducer 98.72% 否
HY-168035 W4275 Inhibitor 98.93% 否
HY-171120 NSD2-PWWP1-IN-2 Inhibitor 99.64% 否
HY-125244 LEM-14-1189 Inhibitor 99.57% 否
HY-157251A UNC8153 Degrader 99.13% 否
HY-161796A UNC8732 TFA Inhibitor 98.00% 否
HY-161796 UNC8732 / 否
HY-114208 BI-9321 Antagonist / 否
HY-124699 MMSET-IN-1 Inhibitor / 否
HY-155817 UNC7096 Chemical / 否
HY-155818 NSD2-IN-4 Inhibitor / 否
HY-161576 Thalidomide-Pip-N-boc / 否
HY-161670 NSD2-PWWP1 ligand 1 Inhibitor / 否
HY-170674 ND-L11B free base Degrader / 否
HY-170674A ND-L11B TFA Degrader / 否
HY-172614 RK-0080552 Inhibitor / 否
HY-175871 (Rac)-NSD2-PWWP1-IN-4 Inhibitor / 否
HY-178321 UNC10088 Degrader / 否
HY-178322 UNC10415667 Degrader / 否
HY-RS09588 NSD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16731 Nsd2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23167 Nsd2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nsd2 NCBI NCBI:7468
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