1. Gene
  2. Bcr - BCR activator of RhoGEF and GTPase Gene

Bcr - BCR activator of RhoGEF and GTPase Gene

种属: Mus musculus

同用名: mKIAA3017; 5133400C09Rik

基因 ID: 110279 | 基因类型: protein coding

关于 Bcr

功能概要

Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including animal organ development; cellular response to lipopolysaccharide; and regulation of vesicle-mediated transport. Located in cytosol; plasma membrane; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; forelimb bud; genitourinary system; and spleen. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; chronic myeloid leukemia; and leukemia. Orthologous to human BCR (BCR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Bcr 基因产物(1)

mRNA Protein Name
NM_001081412.2 NP_001074881.1 breakpoint cluster region protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
17116687 MGI
enables GTPase activator activity IGI
IGI: 通过遗传相互作用推断
19703997 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17000758 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin cytoskeleton organization IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within brain development IGI
IGI: 通过遗传相互作用推断
11684658 MGI
acts upstream of cell migration IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within cellular response to lipopolysaccharide IMP
IMP: 通过突变表型推断
7889565 MGI
acts upstream of or within definitive hemopoiesis IMP
IMP: 通过突变表型推断
7889565 MGI
acts upstream of establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: 通过突变表型推断
7889565 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: 通过遗传相互作用推断
11921339 MGI
acts upstream of or within intracellular protein transmembrane transport IMP
IMP: 通过突变表型推断
7889565 MGI
acts upstream of macrophage migration IGI
IGI: 通过遗传相互作用推断
17116687 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
20962234 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
20962234 MGI
involved in negative regulation of blood vessel remodeling IMP
IMP: 通过突变表型推断
23152932 MGI
involved in negative regulation of cellular extravasation IMP
IMP: 通过突变表型推断
23152932 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
19703997 MGI
acts upstream of or within negative regulation of macrophage migration IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within negative regulation of neutrophil degranulation IGI
IGI: 通过遗传相互作用推断
19703997 MGI
acts upstream of or within negative regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
7889565 MGI
acts upstream of or within negative regulation of respiratory burst IMP
IMP: 通过突变表型推断
7889565 MGI
acts upstream of or within neuromuscular process controlling balance IGI
IGI: 通过遗传相互作用推断
11921339 MGI
acts upstream of neutrophil degranulation IGI
IGI: 通过遗传相互作用推断
19703997 MGI
acts upstream of phagocytosis IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within positive regulation of phagocytosis IGI
IGI: 通过遗传相互作用推断
17116687 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: 通过直接分析推断
11809706 MGI
involved in regulation of vascular permeability IMP
IMP: 通过突变表型推断
23152932 MGI
acts upstream of or within renal system process IMP
IMP: 通过突变表型推断
7889565 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: 通过突变表型推断
19703997 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
20962234 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
20962234 MGI
located in cytosol IDA
IDA: 通过直接分析推断
17116687 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
20962234 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
20962234 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17116687 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
25331951 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

breakpoint cluster region protein

breakpoint cluster region homolog

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bcr NCBI NCBI:613