1. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR
  2. Bcr-Abl Akt
  3. DB07107

DB07107 是一种有效的抗药性 T315I 突变 Bcr-Abl (T315I mutant Bcr-Abl) 酪氨酸激酶抑制剂。DB07107 还是一种有效的 Akt1 抑制剂,IC50 值为 360 nM。

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DB07107 Chemical Structure

DB07107 Chemical Structure

CAS No. : 552332-71-5

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生物活性

DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM[1][2].

IC50 & Target[1][2]

Akt1

360 nM (IC50)

体外研究
(In Vitro)

DB07107 is more effective in blocking drug-resistant T315I mutant than the wild-type Bcr-Abl. DB07107 (C23H22N4O) from DrugBank showed the highest binding energy with XP score of -14.045 kcal/mol[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

370.45

Formula

C23H22N4O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
DB07107
目录号:
HY-123390
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