2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. BTK-IN-34

BTK-IN-34 (compound 9h) 是一种选择性 BTK 抑制剂，通过选择性抑制 pBTK (Tyr223) 在 RAMOS 细胞中显示抗增殖活性，而不影响 Lyn 和 Syk (上游蛋白) BCR 信号通路。

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BTK-IN-34 Chemical Structure

BTK-IN-34 Chemical Structure

CAS No. : 3016419-52-3

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BTK-IN-34 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BTK-IN-34 (compound 9h) is a selective BTK inhibitor. BTK-IN-34 shows antiproliferative activity in RAMOS cells through selective inhibition of pBTK (Tyr223) without affecting Lyn and Syk, upstream proteins in the BCR signaling pathway[1].

体外研究
(In Vitro)

BTK-IN-34（化合物 9h；1-50 μM；24 小时）可降低 RAMOS 细胞中的 pBTK、pERK 1/2 (Thr202/Tyr204) 和 p-p38 (Thr180/Tyr182) 水平[1] 。
BTK-IN-34 对 BTK 高 RAMOS 细胞表现出选择性细胞毒性，IC50 为 2.75 μM。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BTK-IN-34 相关抗体:

Western Blot Analysis[1]

Cell Line: RAMOS cells
Concentration: 1 μM, 10 μM, 50 μM
Incubation Time: 24 hours
Result: Decreased pBTK (Tyr223) levels.
分子量

431.55

Formula

C22H29N3O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BTK-IN-34 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTK-IN-343016419-52-3BtkBruton tyrosine kinaseBTK Inhibitoranti-pBTK activitypERK 1/2,Inhibitorinhibitorinhibit

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目录号：
HY-162257
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