1. Protein Tyrosine Kinase/RTK
    Immunology/Inflammation
  2. Btk
    BMX Kinase
    Toll-like Receptor (TLR)
  3. Poseltinib

Poseltinib (Synonyms: HM71224; LY3337641)

目录号: HY-109010
产品使用指南

Poseltinib 是一种具有口服活性,选择性,不可逆的小分子Bruton酪氨酸激酶 (BTK) 抑制剂,IC50 为 1.95 nM,对 BMX,TEC 和 TXK 的选择性作用分别是 0.3,2.3 和 2.4 倍。Poseltinib可共价结合 BTK 的活性位点 (半胱氨酸 481 残基),同时有效抑制 B 细胞受体 (BCR),Fc受体 (FcR),Toll样受体 (TLR) 介导的信号传导。

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Poseltinib Chemical Structure

Poseltinib Chemical Structure

CAS No. : 1353552-97-2

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Description

Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1].

IC50 & Target

IC50: 1.95 nM (BTK)[1]

Molecular Weight

470.52

Formula

C₂₆H₂₆N₆O₃

CAS No.

1353552-97-2

SMILES

O=C(C=C)NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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产品名称:
Poseltinib
目录号:
HY-109010
需求量:

Poseltinib

Cat. No.: HY-109010