2. Protein Tyrosine Kinase/RTK
  3. Bcr-Abl
  4. Tyrosine kinase-IN-8

Tyrosine kinase-IN-8 (compound 4e) 是一种 BCR‐ABL1 酪氨酸激酶抑制剂 (TKI)。Tyrosine kinase-IN-8 对慢性髓性白血病 (CML) 细胞系 K562 细胞具有抗增殖活性 (CC50=0.8 µM)。Tyrosine kinase-IN-8 可用于慢性白血病的研究。

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Tyrosine kinase-IN-8 Chemical Structure

Tyrosine kinase-IN-8 Chemical Structure

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Tyrosine kinase-IN-8 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tyrosine kinase-IN-8 (compound 4e) is a BCR‐ABL1 tyrosine kinase inhibitor (TKI). Tyrosine kinase-IN-8 shows anti-proliferative activity against K562 cells, a chronic myeloid leukemia (CML) cell line (CC50=0.8 µM). Tyrosine kinase-IN-8 can be used in the study of chronic leukemia[1].

IC50 & Target

Abl1

0.8 μM (CC50)

体外研究
(In Vitro)

Tyrosine kinase-IN-8 (1 和 10 µM， 48 h) 在 K562 细胞系中表现出良好的抗白血病活性， 但对 WSS-1 细胞的毒性也更大[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrosine kinase-IN-8 相关抗体:

Cell Viability Assay[1]

Cell Line: K562 cells and WSS-1 cells
Concentration: 1 and 10 µM
Incubation Time: 48 h
Result: Reduced cell activity at 10μM but had no obvious cytotoxicity at 1μM.
分子量

561.54

Formula

C31H21F2N7O2
非同位 CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tyrosine kinase-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosine kinase-IN-8Bcr-AblTyrosine kinase inhibitorchronic myeloid leukemiaK562 cellsWSS-1 cellsInhibitorinhibitorinhibit

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