2. Gene
  3. Hcn1 - hyperpolarization activated cyclic nucleotide gated potassium channel 1 Gene

Hcn1 - hyperpolarization activated cyclic nucleotide gated potassium channel 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HAC2; Bcng1; C630013B14Rik

基因 ID: 15165 | 基因类型: protein coding

关于 Hcn1

功能概要

Enables cAMP binding activity; cation channel activity; and identical protein binding activity. Involved in cellular response to cAMP and potassium ion transmembrane transport. Acts upstream of or within apical protein localization and retinal cone cell development. Located in axon and dendrite. Is integral component of plasma membrane. Is expressed in brain; heart; and heart ventricle. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcn1 基因产物(1)

mRNA Protein Name
NM_010408.3 NP_034538.2 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cAMP binding IDA
IDA: 通过直接分析推断
22006928 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22006928 MGI
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential EXP
EXP: 通过实验结果推断
21358644 MGI
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential IDA
IDA: 通过直接分析推断
21358644 MGI
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential IMP
IMP: 通过突变表型推断
21358644 MGI
enables intracellularly cAMP-activated cation channel activity IDA
IDA: 通过直接分析推断
30886335 MGI
enables intracellularly cAMP-activated cation channel activity IMP
IMP: 通过突变表型推断
22006928 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15564593 MGI
enables voltage-gated potassium channel activity IMP
IMP: 通过突变表型推断
22006928 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within apical protein localization IMP
IMP: 通过突变表型推断
15564593 MGI
involved in cellular response to cAMP IMP
IMP: 通过突变表型推断
22006928 MGI
acts upstream of or within general adaptation syndrome, behavioral process IDA
IDA: 通过直接分析推断
30886335 MGI
acts upstream of or within neuronal action potential IDA
IDA: 通过直接分析推断
30886335 MGI
involved in potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
22006928 MGI
involved in regulation of postsynaptic membrane potential EXP
EXP: 通过实验结果推断
18093528 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: 通过直接分析推断
18093528 MGI
involved in regulation of postsynaptic membrane potential IMP
IMP: 通过突变表型推断
18093528 MGI
acts upstream of or within retinal cone cell development IMP
IMP: 通过突变表型推断
21052544 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15479642 MGI
located in dendrite IDA
IDA: 通过直接分析推断
15564593 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
18093528 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18093528 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
18093528 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
30886335 MGI
located in plasma membrane IMP
IMP: 通过突变表型推断
22006928 MGI
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
21358644 MGI
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
21358644 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

BCNG-1

HAC-2

brain cyclic nucleotide-gated channel 1

hyperpolarization-activated cation channel 2

hyperpolarization-activated, cyclic nucleotide-gated K+ 1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-18940 Cilobradine / Phase 2
Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13422 Zatebradine hydrochloride Antagonist 99.87% 否
HY-160505 RO-275 Inhibitor 99.0% 否
HY-13422A Zatebradine Antagonist 99.27% 否
HY-W052508 Norquetiapine 99.95% 否
HY-163455 pan-HCN-IN-1 Inhibitor 99.84% 否
HY-108574 CP 339818 hydrochloride Inhibitor 99.61% 否
HY-W052508S Norquetiapine-d8 / 否
HY-114540 CP-339818 Inhibitor / 否
HY-RS06046 HCN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22198 Hcn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28720 Hcn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hcn1 NCBI NCBI:348980
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z