2. Epigenetics Metabolic Enzyme/Protease Immunology/Inflammation
  3. Histone Acetyltransferase Arginase
  4. Conophyllidine

Conophyllidine 是一种双吲哚生物碱，一种选择性的 M2 极化 抑制剂。Conophyllidine 通过作用于 P300/CBP 蛋白的组蛋白乙酰转移酶结构域来抑制组蛋白乙酰化。Conophyllidine 抑制 IL-4 诱导的精氨酸酶 (arginase) 的 IC50 为0.31 μM。Conophyllidine 能够有效地促使肿瘤相关巨噬细胞 (TAMs) 从抗炎型转变为炎症型，从而增强肿瘤微环境中细胞毒性 CD8+T 细胞的募集和功能。Conophyllidine 可用于研究肿瘤相关巨噬细胞。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Conophyllidine

Conophyllidine Chemical Structure

CAS No. : 152406-44-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Conophyllidine 相关抗体

Top Publications Citing Use of Products

查看 Histone Acetyltransferase 亚型特异性产品:

查看所有亚型
CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Conophyllidine, a bisindole alkaloid, is a selective M2 polarization inhibitor. Conophyllidine inhibits histone acetylation by targeting the histone acetyltransferase domain of the P300/CBP proteins. Conophyllidine inhibits IL-4-induced arginase with an IC50 of 0.31 μM. Conophyllidine effectively induces a phenotypic switch in tumor-associated macrophages (TAMs) from an anti-inflammatory to an inflammatory type, thereby enhancing cytotoxic CD8+ T cell recruitment and functionality within the tumor microenvironment. Conophyllidine can be used for the study of TAMs[1].

IC50 & Target[1]

CBP/p300

 

体外研究
(In Vitro)

Conophyllidine (Compound CX-1) (0-1 μM, 12 h) 能够特异性地抑制巨噬细胞 M2 极化，而不会影响 M1 激活[1]。
Conophyllidine (Compound CX-1) (0-1 μM, 12 h) 作用于巨噬细胞 P300/CBP 并抑制组蛋白 H3K27 乙酰化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Conophyllidine 相关抗体:

Immunofluorescence[1]

Cell Line: Macrophages
Concentration: 0.25, 0.5 and 1 μM
Incubation Time: 12 h
Result: Suppressed IL-4 and induced CD206 expression.
Inhibited IL-4-induced expressions of Arg1, Chil3, Retnla, and Mgl2, as well as LPS-induced expressions of Arg1 and IL10.

Western Blot Analysis[1]

Cell Line: Macrophages
Concentration: 50 μM
Incubation Time: 12 h
Result: Did not affect the expression of P300/CBP.
Interacted with the full-length P300, the BD and HAT domains, and the HAT domain with PEG-biotin.
体内研究
(In Vivo)

Conophyllidine (Compound CX-1) (2 mg/kg, i.p., 一天一次共三天) 通过重新编程 B16F10 黑色素瘤和 4T1 乳腺癌模型中的肿瘤相关巨噬细胞，抑制肿瘤进展并激发小鼠的免疫反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 melanoma model established in C57BL/6J mice[1]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 3 days
Result: Significantly delayed tumor growth, prolonged the survival of mice without body weight loss.
Induced upregulation of the macrophage population.
Inhibited the CD206 expression and elevated the MHCII expression.
Upregulated the population of tumor-infiltrating CD8+ T cells and did not affect the population of CD4+ T cells Elevated the expressions of IFNγ, GzmB, and TNFα.
Animal Model: 4T1 breast cancer model established in BALB/c or BALB/c nu/nu mice[1]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 3 days
Result: Inhibited lung metastasis of breast cancer.
分子量

778.89

Formula

C44H50N4O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Conophyllidine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Conophyllidine152406-44-5Histone AcetyltransferaseArginaseHATsHATBisindoleCX-1Tumor-associated macrophagesCD8+Tumor immunityP300/CBPInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Conophyllidine
目录号：
HY-175180
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z