2. Gene
  3. PGAM5 - PGAM family member 5, mitochondrial serine/threonine protein phosphatase Gene

PGAM5 - PGAM family member 5, mitochondrial serine/threonine protein phosphatase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PGAM 家族成员 5，线粒体丝氨酸/苏氨酸蛋白磷酸酶

种属: Homo sapiens

同用名: BXLBV68

基因 ID: 192111 | 基因类型: protein coding

关于 PGAM5

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:132,710,842-132,722,734 (from NCBI)

This gene has 5 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.7) and 25 other tissues.

功能概要

启用 GTPase 激活剂活性和蛋白丝氨酸/苏氨酸磷酸酶活性。参与坏死过程。位于线粒体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activator activity and protein serine/threonine Phosphatase activity. Involved in necroptotic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PGAM5 基因产物(3)

mRNA Protein Name
NM_001170543.2 NP_001164014.1 serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 1
NM_001170544.2 NP_001164015.1 serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 2
NM_138575.4 NP_612642.2 serine/threonine-protein phosphatase PGAM5, mitochondrial isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IMP
IMP: 通过突变表型推断
22265414 GOA
enables phosphoprotein phosphatase activity IMP
IMP: 通过突变表型推断
22265414 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19590015 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: 通过直接分析推断
19590015 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
22265414 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in necroptotic process IMP
IMP: 通过突变表型推断
22265414 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
22915595 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PGAM5 蛋白结构

His_Phos_1

His_Phos_1: Histidine phosphatase superfamily (branch 1) (99 - 236)

  • 0
  • 100
  • 200
  • 289 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase PGAM5, mitochondrial

Bcl-XL-binding protein v68

PGAM5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PGAM5 Q96HS1 MAP3K5 Homo sapiens Q99683
Anti Tag CoIP
19590015
种属间: 跨种属相互作用 种属内: 同种属相互作用

PGAM5 抗体

目录号 产品名 应用 反应物种
HY-P87008 PGAM5 Antibody (YA6701) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139598 LFHP-1c Inhibitor 98.01% 否
HY-RS10376 PGAM5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17555 Pgam5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24013 Pgam5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PGAM5 VGNC VGNC:100087
Bos taurus PGAM5 VGNC VGNC:32780
Mus musculus PGAM5 MGD MGI:1919792
Rattus norvegicus PGAM5 RGD RGD:1312028
Canis familiaris PGAM5 VGNC VGNC:52956
Others PGAM5 NCBI
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