Stat6 - signal transducer and activator of transcription 6 Gene

中文名称：信号转导和转录激活因子 6

种属: Rattus norvegicus

关于 Stat6

功能概要

该基因编码的蛋白可启动 DNA 结合转录因子活性和序列特异性 DNA 结合活性。参与多个过程，包括细胞对过氧化氢的反应；细胞对活性氮物质的反应；和 RNA 聚合酶 II 对转录的正调控。位于膜筏和细胞核内。用于研究哮喘和肾纤维化。哮喘和心肌炎的生物标志物。该基因的人类直系同源物与类脂肾病有关；前列腺癌；和尿血吸虫病。与人类 STAT6（信号转导和转录激活因子 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to reactive nitrogen species; and positive regulation of transcription by RNA polymerase II. Located in membrane raft and nucleus. Used to study asthma and renal fibrosis. Biomarker of asthma and myocarditis. Human ortholog(s) of this gene implicated in lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]