LIMK1 - LIM domain kinase 1 Gene

中文名称：LIM 结构域激酶 1

种属: Homo sapiens

同用名: LIMK; LIMK-1

基因 ID: 3984 | 基因类型: protein coding

关于 LIMK1

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:74,083,804-74,122,525 (from NCBI)

This gene has 8 transcripts (splice variants), 262 orthologues, 23 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 15.7), spleen (RPKM 11.2) and 25 other tissues.

功能概要

大约有 40 种已知的真核 LIM 蛋白，以它们包含的 LIM 结构域命名。 LIM 结构域是高度保守的富含半胱氨酸的结构，包含 2 个锌指。尽管锌指通常通过与 DNA 或 RNA 结合发挥作用，但 LIM 基序可能介导蛋白质-蛋白质相互作用。 LIM 激酶 1 和 LIM 激酶 2 属于一个小亚家族，具有 2 个 N 末端 LIM 基序和一个 C 末端蛋白激酶结构域的独特组合。 LIMK1 是一种丝氨酸/苏氨酸激酶，可通过肌动蛋白结合因子 cofilin 的磷酸化和失活来调节肌动蛋白聚合。这种蛋白质在发育过程中普遍表达，并在许多与细胞骨架结构相关的细胞过程中发挥作用。这种蛋白质还可以刺激轴突生长，并可能在大脑发育中发挥作用。 LIMK1 半合子与威廉姆斯综合征的视觉空间建设性认知受损有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 2 月]

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

LIMK1 基因产物(3)

mRNA	Protein	Name
NM_016735.1
NM_002314.4	NP_002305.1	LIM domain kinase 1 isoform 1
NM_001204426.2	NP_001191355.1	LIM domain kinase 1 isoform 2

LIMK1 蛋白结构

LIM

PDZ

Pkinase_Tyr

0
100
200
300
400
500
600
647 a.a.

蛋白主名

其他名称

LIM domain kinase 1

LIM motif-containing protein kinase

关联疾病

疾病名称

别名

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Williams-Beuren Region Duplication Syndrome

Chromosome 7q11.23 Duplication Syndrome	7q11.23 Duplication Syndrome
7q11.23 Microduplication Syndrome	Wbs Duplication Syndrome
Somerville-Van Der Aa Syndrome	Dup(7)(Q11.23)
Trisomy 7q11.23	William-Beuren Region Duplication Syndrome
Chromosome 7q11.23 Duplication

Fragile X Syndrome

FXS	Martin-Bell Syndrome
Fraxa Syndrome	Marker X Syndrome
X-Linked Mental Retardation And Macroorchidism	Fragile X Mental Retardation Syndrome
Fra Syndrome	Mental Retardation, X-Linked, Associated With Marxq28
Frax Syndrome	Symptomatic Form Of Fragile X Syndrome In Female Carriers
Fragile-X Syndrome	Fraxe Syndrome

Supravalvular Aortic Stenosis

SVAS	Supravalvar Aortic Stenosis
Supravalvar Aortic Stenosis, Eisenberg Type	Aortic Supravalvular Stenosis
Aortic Stenosis, Supravalvular	Supra-Valvular Aortic Stenosis
Stenosis, Aortic Supravalvular	Stenosis, Supravalvular Aortic
Supravalvular Stenosis, Aortic	Aortic Stenosis Supravalvular

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-18305	BMS-5	Inhibitor	99.51%	否
HY-122630	TH-257	Inhibitor	98.01%	否
HY-18304	BMS-3	Inhibitor	99.46%	否
HY-19353	SR7826	Inhibitor	98.74%	否
HY-120097	R-10015	Inhibitor	99.72%	否
HY-151539	TH470	Inhibitor	99.57%	否
HY-148061	DB1113		99.28%	否
HY-120025	CRT0105950	Inhibitor	99.91%	否
HY-128062	LIMK1 inhibitor BMS-4	Inhibitor	≥99.0%	否
HY-14227	LIMK-IN-1	Inhibitor	/	否
HY-N10868	8β,9α-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	LIMK1	MGD	MGI:104572
Bos taurus	LIMK1	VGNC	VGNC:30890
Rattus norvegicus	LIMK1	RGD	RGD:62055
Canis familiaris	LIMK1	VGNC	VGNC:42681
Felis catus	LIMK1	VGNC	VGNC:68053
Macaca mulatta	LIMK1	VGNC	VGNC:74269
Others	LIMK1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

LIMK1 - LIM domain kinase 1 Gene

关于 LIMK1

功能概要

LIMK1 基因产物(3)

LIMK1 蛋白结构

关联疾病

直系同源

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LIMK1 - LIM domain kinase 1 Gene

关于 LIMK1

功能概要

LIMK1 基因产物(3)

LIMK1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z