2. Gene
  3. Bche - butyrylcholinesterase Gene

Bche - butyrylcholinesterase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：丁酰胆碱酯酶

种属: Rattus norvegicus

基因 ID: 65036 | 基因类型: protein coding

关于 Bche

Primary_assembly 2: 158,307,584-158,401,148 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 130 orthologues, 27 paralogues and is associated with 57 phenotypes. Biased expression in Heart (RPKM 176.5), Liver (RPKM 64.) and 8 other tissues.

功能概要

该基因编码的蛋白可启动胆碱结合活性和胆碱酯酶活性。参与多个过程，包括成神经细胞分化；对叶酸的反应；和对糖皮质激素的反应。位于内质网腔；细胞外空间；和膜。用于研究遗忘症和高同型半胱氨酸血症。钩端螺旋体病和锥虫病的生物标志物。该基因的人类直系同源物与阿尔茨海默病有关；冠状动脉疾病（多发性）；糖尿病（多发性）；癫痫;和遗传性代谢紊乱。与人类 BCHE（丁酰胆碱酯酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables choline binding activity and cholinesterase activity. Involved in several processes, including neuroblast differentiation; response to folic acid; and response to glucocorticoid. Located in endoplasmic reticulum lumen; extracellular space; and membrane. Used to study amnestic disorder and hyperhomocysteinemia. Biomarker of leptospirosis and trypanosomiasis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease (multiple); diabetes mellitus (multiple); epilepsy; and inherited metabolic disorder. Orthologous to human BChE (butyrylcholinesterase). [provided by Alliance of Genome Resources, Apr 2022]

Bche 基因产物(1)

mRNA Protein Name
NM_022942.1 NP_075231.1 cholinesterase precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables choline binding IDA
IDA: 通过直接分析推断
126256 RGD
enables cholinesterase activity IDA
IDA: 通过直接分析推断
126256 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in choline metabolic process IDA
IDA: 通过直接分析推断
126256 RGD
involved in learning IDA
IDA: 通过直接分析推断
16275899 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21771623 RGD
involved in negative regulation of synaptic transmission IDA
IDA: 通过直接分析推断
16275899 RGD
involved in neuroblast differentiation IMP
IMP: 通过突变表型推断
21771623 RGD
involved in response to alkaloid IDA
IDA: 通过直接分析推断
17159811 RGD
involved in response to folic acid IDA
IDA: 通过直接分析推断
16442260 RGD
involved in response to glucocorticoid IDA
IDA: 通过直接分析推断
16179131 RGD
involved in response to nutrient IDA
IDA: 通过直接分析推断
15002734 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16572919 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
1133098 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
17194019 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bche 蛋白结构

COesterase

COesterase: pfam00135 (24 - 544)

AChE_tetra

AChE_tetra: pfam08674 (559 - 593)

  • 0
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  • 400
  • 500
  • 597 a.a.
蛋白主名 其他名称

cholinesterase

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17368 Rivastigmine Inhibitor 99.93% 是
HY-107922 Ethopropazine hydrochloride Inhibitor 99.26% 否
HY-B1488 Tacrine hydrochloride Inhibitor 99.90% 否
HY-B2244 Tacrine hydrochloride (hydrate) Inhibitor 99.98% 否
HY-B1239 Drofenine hydrochloride Inhibitor 98.10% 否
HY-100919 Ambenonium chloride Inhibitor 96.18% 是
HY-B1542A Benactyzine hydrochloride Inhibitor 99.02% 否
HY-16183 Echothiopate iodide Inhibitor / 否
Pre-clinical Phase
生物活性分子 (140)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0285 Imperatorin Inhibitor 98.72% 否
HY-107569 Garcinol Inhibitor 99.0% 否
HY-N0226A Epiberberine chloride Inhibitor 99.02% 否
HY-N4225 Aaptamine Inhibitor 99.71% 否
HY-W130025 p-Xylene bis(pyridinium bromide) Inhibitor 99.60% 否
HY-N2157 Pteryxin Inhibitor 99.96% 否
HY-122140 ACG548B Inhibitor 99.72% 否
HY-155140 BChE-IN-17 Inhibitor 99.07% 否
HY-107275 Ebeiedinone Inhibitor 99.51% 否
HY-121072 ASS234 Inhibitor 99.6% 否
HY-119577 Ubretid 99.0% 是
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% 否
HY-N2960 Broussonin A Inhibitor 97% 否
HY-N2284 Sophoflavescenol Inhibitor 98.78% 否
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% 否
HY-N0226 Epiberberine Inhibitor 98.46% 否
HY-149212 SD-6 Inhibitor ≥98.0% 否
HY-103373 PE154 Inhibitor 99.01% 否
HY-N7346 Lucidadiol Inhibitor 98.0% 否
HY-162340 Z32439948 Inhibitor / 否
HY-151436 ZLMT-12 Inhibitor / 否
HY-131971 AChE/BChE-IN-1 Inhibitor / 否
HY-170938 AChE-IN-82 Inhibitor / 否
HY-159081 AChE/BChE-IN-20 Inhibitor / 否
HY-162681 eeAChE-IN-3 Inhibitor / 否
HY-163883 BChE-IN-34 Inhibitor / 否
HY-161507 hCAI/II-IN-8 Inhibitor / 否
HY-168301 CL-13 Inhibitor / 否
HY-155085 hAChE-IN-3 Inhibitor / 否
HY-161331 S16–1029 Inhibitor / 否
HY-N10488 BChE-IN-11 Inhibitor / 否
HY-157437 AChE/BChE-IN-16 Inhibitor / 否
HY-144762 K027 Inhibitor / 否
HY-146687 BuChE-IN-4 Inhibitor / 否
HY-170561 AChE/BuChE-IN-6 Inhibitor / 否
HY-168052 hAChE-IN-9 Inhibitor / 否
HY-149243 BChE-IN-16 Inhibitor / 否
HY-169234 BChE-IN-35 Inhibitor / 否
HY-N10917 Xanthohumol I Inhibitor / 否
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / 否
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / 否
HY-159898 AChE/BChE-IN-23 Inhibitor / 否
HY-127087 Isogarcinol Inhibitor / 否
HY-149300 SB-1436 Inhibitor / 否
HY-N15710 Magnotriol B Inhibitor / 否
HY-173152 AChE/BChE-IN-26 Inhibitor / 否
HY-162338 BChE-IN-29 Inhibitor / 否
HY-108048A Desoxypeganine hydrochloride Inhibitor / 否
HY-174464 AChE/BChE-IN-28 Inhibitor / 否
HY-172460 AChE/BChE/MAO-B-IN-5 Inhibitor / 否
HY-157982 BChE-IN-28 Inhibitor / 否
HY-146251 BuChE-IN-6 Inhibitor / 否
HY-152632 BuChE-IN-7 Inhibitor / 否
HY-163514 hAChE-IN-8 Inhibitor / 否
HY-175211 BChE-IN-42 Inhibitor / 否
HY-175524 BChE/MAO-B-IN-2 Inhibitor / 否
HY-163909 AChE-IN-72 Inhibitor / 否
HY-158092 ChEs/MAOs-IN-2 Inhibitor / 否
HY-149087 MR2938 Inhibitor / 否
HY-161150 AChE/BChE-IN-17 Inhibitor / 否
HY-N10781 Isograndifoliol Inhibitor / 否
HY-159880 AChE/BChE-IN-24 Inhibitor / 否
HY-149211 AChE/BChE-IN-12 Inhibitor / 否
HY-161842 AChE-IN-67 Inhibitor / 否
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / 否
HY-168731 AChE/BChE-IN-25 Inhibitor / 否
HY-158261 AChE-IN-63 Inhibitor / 否
HY-146669 BChE-IN-6 Inhibitor / 否
HY-N10490 Blestrin D Inhibitor / 否
HY-178017 BChE/hCA II-IN-1 Inhibitor / 否
HY-163537 AChE/BuChE-IN-5 Inhibitor / 否
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / 否
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / 否
HY-159482 SBN-284 Inhibitor / 否
HY-N10701 AChE/BChE-IN-11 Inhibitor / 否
HY-163441 BChE-IN-31 Inhibitor / 否
HY-158696 BChE/MAO-B-IN-1 Inhibitor / 否
HY-174399 AChE/BChE-IN-27 Inhibitor / 否
HY-151405 Z164597606 Inhibitor / 否
HY-150545 AChE-IN-21 Inhibitor / 否
HY-146315 AChE/BChE-IN-6 Inhibitor / 否
HY-161156 BChE-IN-26 Inhibitor / 否
HY-N10489 BChE-IN-12 Inhibitor / 否
HY-163746 BuChE-IN-11 Inhibitor / 否
HY-152232 BChE-IN-15 Inhibitor / 否
HY-161453 BChE-IN-32 Inhibitor / 否
HY-149090 AChE/BuChE/MAO-B-IN-2 / 否
HY-175655 BChE/p38-α MAPK-IN-1 Inhibitor / 否
HY-172461 MAO-IN-6 Inhibitor / 否
HY-170417 hAChE/hBuChE/GSK-3β-IN-1 Inhibitor / 否
HY-121191 Bisnorcymserine Inhibitor / 否
HY-157384 BChE-IN-22 Inhibitor / 否
HY-108048 Desoxypeganine Inhibitor / 否
HY-161508 AChE/BChE-IN-19 Inhibitor / 否
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / 否
HY-162693 AChE-IN-68 Inhibitor / 否
HY-162671 BuChE-IN-12 Inhibitor / 否
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / 否
HY-147939 AChE/BuChE-IN-3 Inhibitor / 否
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / 否
HY-155366 hAChE-IN-6 Inhibitor / 否
HY-158334 NDs-IN-1 Inhibitor / 否
HY-153432 TRV-7019 99.64% 否
HY-169962 hCA I-IN-4 Inhibitor / 否
HY-157978 AChE-IN-59 Inhibitor / 否
HY-170976 BuChE-IN-16 / 否
HY-169961 BChE-IN-38 Inhibitor / 否
HY-149993 hBChE-IN-2 Inhibitor / 否
HY-172782 BuChE-IN-20 Inhibitor / 否
HY-150585 BuChE-IN-5 Inhibitor / 否
HY-169162 hBChE-IN-3 Inhibitor / 否
HY-169163 BChE-IN-36 Inhibitor / 否
HY-175658 AChE/BChE-IN-29 Inhibitor / 否
HY-159143 BChE-IN-33 Inhibitor / 否
HY-156031 BChE-IN-19 Inhibitor / 否
HY-157382 AChE-IN-51 Inhibitor / 否
HY-N7708 Lycodoline Inhibitor / 否
HY-157981 AChE-IN-60 Inhibitor / 否
HY-N10486 BChE-IN-10 Inhibitor / 否
HY-174328 BChE/AChE-IN-1 Inhibitor / 否
HY-149273 hBChE-IN-1 Inhibitor / 否
HY-143465 BChE-IN-5 Inhibitor / 否
HY-175523 MAO-B-IN-48 Inhibitor / 否
HY-170389 BChE-IN-39 Inhibitor / 否
HY-172219 CUR-IPA Inhibitor / 否
HY-N12581 Kuwanon U Inhibitor / 否
HY-N16129 Diplacone Inhibitor / 否
HY-162812 H3R antagonist 4 Inhibitor / 否
HY-162639 α-Glucosidase-IN-68 Inhibitor / 否
HY-W130236 Methylene Violet 3RAX Inhibitor 95.54% 否
HY-158978 Multitarget AD inhibitor-2 Inhibitor / 否
HY-144446 BuChE-IN-1 Inhibitor / 否
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / 否
HY-161643 S21-1011 Inhibitor / 否
HY-114422 ARRY-371797 Inhibitor / 否
HY-155284 K1833 Inhibitor / 否
HY-159977 1,2-Didehydrotanshinone IIA Inhibitor / 否
HY-W185336 Dibutyl phenyl phosphate Inhibitor / 否
HY-W049312 7-Methoxytacrine Inhibitor / 否
HY-B1542 Benactyzine Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bche NCBI NCBI:590
Mus musculus Bche NCBI NCBI:12038
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