1. Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. AChE
    iGluR
  3. Tacrine hydrochloride

Tacrine hydrochloride 

目录号: HY-B1488 纯度: >98.0%
产品使用指南

Tacrine hydrochloride 是一种 AChEBChE 的有效抑制剂,IC50 值分别为 31 nM 和 25.6 nM 。Tacrine hydrochloride 也是 NMDAR 的抑制剂, IC50 值为 26 μM。Tacrine hydrochloride 可用于研究阿尔茨海默氏症。

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Tacrine hydrochloride Chemical Structure

Tacrine hydrochloride Chemical Structure

CAS No. : 1684-40-8

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Size Price Stock Quantity
10 mM * 1 mL in Water ¥660 In-stock
100 mg ¥600 In-stock
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Description

Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].

IC50 & Target

IC50: 31 nM (AChE), 25.6 nM (BChE), 26 μM (NMDAR)[1][2]

In Vitro

Tacrine (12.5-37.5 nM) inhibits venom acetylcholinesterase as well as human serum butyrylcholinesterase in a concentration-dependent manner[1].
Tacrine reduces the neurotoxicity induced by the activation of the NMDARs in murine cortical neuronal cultures with an IC50of ~500 μM[2].
Tacrine inhibits the NMDAR responses in a concentration-dependent manner with an IC50 of ~190 μM at -60 mV[2].

In Vivo

Tacrine (20-40 μmol/kg; s.c.) disrupts retention of learning in 17- and 30-day old mice in passive avoidance, and while the low dose of tacrine treatment (5 μmol/kg; s.c.) improves retention in 17-day old mice[2].
Tacrine (0.1-0.4 mg/mL; i.p. for 7 d) inhibits the expression of AChE, but does not significantly improve the protection of the retina function and morphology in mice[3].

Molecular Weight

234.72

Formula

C₁₃H₁₅ClN₂

CAS No.

1684-40-8

中文名称

盐酸他克林

SMILES

NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (355.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2604 mL 21.3020 mL 42.6040 mL
5 mM 0.8521 mL 4.2604 mL 8.5208 mL
10 mM 0.4260 mL 2.1302 mL 4.2604 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。 -80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

References
  • 摩尔计算器

  • 稀释计算器

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Keywords:

TacrineAChEiGluRAcetylcholinesteraseIonotropic glutamate receptorsBChENMDARAlzheimerInhibitorinhibitorinhibit

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产品名称:
Tacrine hydrochloride
目录号:
HY-B1488
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