Trpv4 - transient receptor potential cation channel, subfamily V, member 4 Gene

种属: Rattus norvegicus

同用名: Vroac; Otrpc4

基因 ID: 66026 | 基因类型: protein coding

关于 Trpv4

功能概要

Enables Calcium Channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including calcium ion transport; Cytoskeleton organization; and positive regulation of microtubule depolymerization. Located in several cellular components, including focal adhesion; lamellipodium; and ruffle membrane. Colocalizes with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpv4 基因产物(1)

mRNA	Protein	Name
NM_023970.1	NP_076460.1	transient receptor potential cation channel subfamily V member 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin binding	IDA IDA: 通过直接分析推断	20657843	RGD
enables actin filament binding	IDA IDA: 通过直接分析推断	20657843	RGD
enables alpha-tubulin binding	IDA IDA: 通过直接分析推断	20657843	RGD
enables beta-tubulin binding	IDA IDA: 通过直接分析推断	20657843	RGD
enables calcium channel activity	IDA IDA: 通过直接分析推断	20657843	RGD
enables calcium channel activity	IMP IMP: 通过突变表型推断	23136043	RGD
enables microtubule binding	IDA IDA: 通过直接分析推断	20657843	RGD
enables monoatomic cation channel activity	IDA IDA: 通过直接分析推断	11081638	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	20650893	RGD
enables protein kinase C binding	IDA IDA: 通过直接分析推断	20657843	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin cytoskeleton organization	IDA IDA: 通过直接分析推断	20657843	RGD
involved in actin filament organization	IDA IDA: 通过直接分析推断	20657843	RGD
involved in calcium ion import	IDA IDA: 通过直接分析推断	20657843	RGD
involved in calcium ion transmembrane transport	IMP IMP: 通过突变表型推断	23136043	RGD
involved in cortical microtubule organization	IDA IDA: 通过直接分析推断	20657843	RGD
involved in hypotonic response	IDA IDA: 通过直接分析推断	11081638	RGD
involved in microtubule polymerization	IDA IDA: 通过直接分析推断	20657843	RGD
involved in multicellular organismal-level water homeostasis	IMP IMP: 通过突变表型推断	23136043	RGD
involved in negative regulation of neuron projection development	IDA IDA: 通过直接分析推断	20657843	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	20650893	RGD
involved in positive regulation of microtubule depolymerization	IDA IDA: 通过直接分析推断	20657843	RGD
involved in positive regulation of striated muscle contraction	IMP IMP: 通过突变表型推断	32706268	RGD
involved in positive regulation of vascular permeability	IMP IMP: 通过突变表型推断	23136043	RGD
NOT involved in regulation of blood pressure	IMP IMP: 通过突变表型推断	23136043	RGD
NOT involved in regulation of heart rate	IMP IMP: 通过突变表型推断	23136043	RGD
NOT involved in regulation of response to osmotic stress	IMP IMP: 通过突变表型推断	23136043	RGD
involved in response to hypoxia	IEP IEP: 通过表达模式推断	22962011	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	20650893	RGD
located in cortical actin cytoskeleton	IDA IDA: 通过直接分析推断	20657843	RGD
located in cytoplasmic microtubule	IDA IDA: 通过直接分析推断	20657843	RGD
located in filopodium	IDA IDA: 通过直接分析推断	20657843	RGD
located in focal adhesion	IDA IDA: 通过直接分析推断	20657843	RGD
located in growth cone	IDA IDA: 通过直接分析推断	20657843	RGD
located in lamellipodium	IDA IDA: 通过直接分析推断	20657843	RGD
located in ruffle membrane	IDA IDA: 通过直接分析推断	20657843	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transient receptor potential cation channel subfamily V member 4

VR-OAC	osm-9-like TRP channel 4
osmosensitive transient receptor potential channel 4	transient receptor potential cation channel subf V memb 4
transient receptor potential cation channel, subfamily 5, member 4	vanilloid receptor-related osmotically a

Trpv4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Trpv4	Q9ERZ8	Aqp4	Rattus norvegicus	P47863	Anti Bait CoIP	21262839
种属内	Trpv4	Q9ERZ8	Aqp4	Rattus norvegicus	P47863-1	Anti Bait CoIP	21262839

种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-19765	GSK2798745	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

生物活性分子 (36)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19608	GSK1016790A		99.93%	否
HY-100208	HC-067047	Antagonist	99.89%	否
HY-100720	GSK2193874	Antagonist	99.91%	否
HY-120691A	GSK205	Antagonist	99.47%	否
HY-101507	Zerencotrep	Inhibitor	99.47%	否
HY-19975	RN-1734	Antagonist	99.75%	否
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	否
HY-18662	RQ-00203078	Antagonist	99.84%	否
HY-N8264	Moringin	Agonist	99.95%	否
HY-19976	RN-1747	Agonist	99.27%	否
HY-114400	TRPV4 agonist-1 free base	Agonist	99.69%	否
HY-120963	N-Oleoyl Taurine		99.9%	否
HY-116291	4α-Phorbol 12,13-didecanoate		99.30%	否
HY-160603	PF-05214030	Antagonist	99.19%	否
HY-110270	RN-9893	Antagonist	99.91%	否
HY-120962	N-Arachidonoyl Taurine	Activator	99.0%	否
HY-176464	GSK2220691	Inhibitor	/	否
HY-160900	RN-1665	Antagonist	99.93%	否
HY-124001	N-Docosanoyl taurine	Activator	99.0%	否
HY-120514	JNc-440		98.04%	否
HY-162765	TRPV4-IN-5	Inhibitor	98.77%	否
HY-114400A	TRPV4 agonist-1	Agonist	/	否
HY-110270A	RN-9893 hydrochloride	Antagonist	/	否
HY-117372	DFL23448	Antagonist	/	否
HY-142620	TRPV4 antagonist 3	Antagonist	/	否
HY-149823	TRPV4 antagonist 4	Antagonist	/	否
HY-157712	08:0 PI(4,5)P2 ammonium		/	否
HY-178236	TRPM5 agonist-1	Inhibitor	/	否
HY-178509	TRPV4-KCa2.3 modulator 1	Activator	/	否
HY-P5315	eNOS pT495 decoy peptide	Activator	/	否
HY-RS15124	TRPV4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-W721480	HC-067047 hydrochloride	Antagonist	/	否
HY-N2940	Bisandrographolide A	Activator	/	否
HY-RS16623	Trpv4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23058	Trpv4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-112202	GSK3395879	Antagonist	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Trpv4	NCBI	NCBI:59341

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