1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. GSK2798745

GSK2798745 

目录号: HY-19765
产品使用指南

GSK2798745 是一流的,高效的,选择性的且具有口服活性的 瞬时受体电位香草酸 4 (TRPV4) 离子通道阻断剂,对于 hTRPV4 和 rTRPV4 的 IC50 值分别为 1.8 和 1.6 nM。GSK2798745 用于治疗与充血性心力衰竭相关的肺水肿的研究。

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GSK2798745 Chemical Structure

GSK2798745 Chemical Structure

CAS No. : 1419609-94-1

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Description

GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure[1][2].

IC50 & Target

IC50: 1.8 nM (hTRPV4) and 1.6 nM (rTRPV4)[2]

Molecular Weight

460.53

Formula

C₂₅H₂₈N₆O₃

CAS No.

1419609-94-1

SMILES

N#CC1=CC=C2N=CN(C[C@](CCC3)(C)C[C@@]43CN(C5=NC=C(C(C)(O)C)N=C5)C(O4)=O)C2=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
GSK2798745
目录号:
HY-19765
需求量:

GSK2798745

Cat. No.: HY-19765