2. Immunology/Inflammation NF-κB Apoptosis
  3. Toll-like Receptor (TLR) NF-κB Caspase TNF Receptor Interleukin Related
  4. GlcNAc-MurNAc

GlcNAc-MurNAc 是一种二糖和一种温和的 TLR4 激动剂，对小鼠 TLR4 的 Kd 为 383 μM。GlcNAc-MurNAc 直接与 TLR4 结合，并激活其下游的 NF-κB 和 IRF 通路。GlcNAc-MurNAc 通过 TLR4 依赖性机制改善 Dextran sulfate sodium salt (DSS) (HY-116282C) 诱导的小鼠结肠炎。GlcNAc-MurNAc 可用于炎症性肠病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GlcNAc-MurNAc

GlcNAc-MurNAc Chemical Structure

CAS No. : 4500-70-3

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

GlcNAc-MurNAc 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GlcNAc-MurNAc, a disaccharide, is a TLR4 agonist with a Kd of 383 μM for murine TLR4. GlcNAc-MurNAc directly binds to TLR4 and activates its downstream NF-κB and IRF pathways. GlcNAc-MurNAc improves Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis in mice through a TLR4-dependent mechanism. GlcNAc-MurNAc can be used for the study of inflammatory bowel disease[1].

IC50 & Target[1]

TLR4

383 μM (Kd)

NF-κB

 

IL-6

 

IL-12

 

IL-1α

 

体外研究
(In Vitro)

GlcNAc-MurNAc (GM) (1-8 mM, 24 h) 在 RAW264.7、BMDMs 和 THP-1 细胞中通过不依赖于 NOD 的机制而具有免疫活性[1]。
GlcNAc-MurNAc (4 mM, 24 h) 依赖 TLR4 来激活野生型骨髓源性巨噬细胞 (BMDMs) 的免疫反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GlcNAc-MurNAc 相关抗体:

ELISA Assay[1]

Cell Line: RAW264.7, BMDMs and THP-1 cells
Concentration: 1, 2, 4 mM for RAW264.7 cells; 2, 4, 8 mM for BMDMs and THP-1 cells
Incubation Time: 24 h
Result: Upregulated expression and production of proinflammatory cytokines TNF-α and IL-6.
Appeared less potent monosaccharide M.
Suppressed TNF-α production in RAW264.7 cells with the addition of TAK-242, a selective TLR4 inhibitor.

RT-PCR[1]

Cell Line: WT and Tlr4-/- BMDMs
Concentration: 4 mM
Incubation Time: 24 h
Result: Significantly upregulated some cytokine and chemokine genes, including IL12a/b, IL6, IL1a/b, Csf3, Ccl5, and Cxcl1 in WT cells but failed in Tlr4-/- cells.
体内研究
(In Vivo)

GlcNAc-MurNAc (GM) (10 mg/kg, i.p., once daily for 9 days) 以TLR 4依赖性机制减轻 DSS 诱导的小鼠结肠炎[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS-induced colitis model established in 7-9 weeks WT and Tlr4-/- C57BL/6 J mice[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), once daily for 9 days (2 days before the DDS water administration)
Result: Alleviated colitis in WT mice, as evidenced by reduced body weight loss and colonic shortening in WT group.
Significantly reduced monocytes and neutrophils, in the colonic lamina propria in WT group.
Suppressed colonic expressions of proinflammatory genes, such as Tnfa, IL1b, and Ccl2 in WT group.
Restored the elevation of inflammatory markers, including IL-6, IFN-β, IL-27, IL-10, and IL-23 in WT group.
Failed to prevent weight loss and colonic shortening in Tlr4-/- group.
分子量

496.46

Formula

C19H32N2O13
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GlcNAc-MurNAc 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GlcNAc-MurNAc4500-70-3Toll-like Receptor (TLR)NF-κBCaspaseTNF ReceptorInterleukin RelatedNuclear factor-κBNuclear factor-kappaBTumor Necrosis Factor ReceptorTNFRILColitisGut microbiotaInflammatory bowel diseaseBone-marrow-derived macrophagesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GlcNAc-MurNAc
目录号：
HY-175222
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z