2. Neuronal Signaling
  3. Amyloid-β
  4. Glutaminyl Cyclase Inhibitor 5

Glutaminyl Cyclase Inhibitor 5 

目录号: HY-152031
产品使用指南

摩尔计算器

Glutaminyl Cyclase Inhibitor 5 (Compound 71) 是一种有效的、选择性的人谷氨酰胺酰基环化酶 (hQC) 抑制剂，IC50 为 3.2 nM。

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Glutaminyl Cyclase Inhibitor 5 Chemical Structure

Glutaminyl Cyclase Inhibitor 5 Chemical Structure

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Glutaminyl Cyclase Inhibitor 5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glutaminyl Cyclase Inhibitor 5 (Compound 71) is a potent and selective human glutaminyl cyclase (hQC) inhibitor with an IC50 of 3.2 nM[1].

IC50 & Target

IC50: 3.2 nM (hQC), 34.2 nM (mQC), 106.1 nM (isoQC)[1]
体外研究
(In Vitro)

Glutaminyl Cyclase Inhibitor 5 (Compound 71) 未表现出明显的 hERG 抑制 (10 μM 抑制率为 47.6%)[1]。
Glutaminyl Cyclase Inhibitor 5 可能透过血脑屏障 (-log Pe = 5.5)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glutaminyl Cyclase Inhibitor 5 相关抗体:
体内研究
(In Vivo)

Glutaminyl Cyclase Inhibitor 5 (Compound 71) (10 mM, 5 μL; ICV; once) 抑制急性阿尔茨海默病小鼠模型中 pE-Aβ3-40 形成，抑制率为 25%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, six weeks old), acute Alzheimer's disease model[1]
Dosage: 10 mM, 5 μL
Administration: Intracerebroventricular injection, once
Result: Suppressed the formation of pE-Aβ3-40 by 25.0%.
分子量

394.51

Formula

C22H30N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Glutaminyl Cyclase Inhibitor 5 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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