1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. iGluR
  3. GNE-8324

GNE-8324 是一种选择性的 GluN2A 阳性变构调节剂。GNE-8324 在抑制性但非兴奋性神经元中选择性增强 NMDA 受体 (NMDAR) 介导的突触反应。

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GNE-8324 Chemical Structure

GNE-8324 Chemical Structure

CAS No. : 1698901-76-6

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  • 生物活性

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生物活性

GNE-8324 is a selective GluN2A positive allosteric modulator. GNE-8324 selectively enhances NMDA receptor (NMDAR)-mediated synaptic responses in inhibitory but not excitatory neurons[1].

体外研究
(In Vitro)

A reciprocal allosteric interaction between the GNE-8324 and glutamate binding sites at GluN2A NMDARs such that binding of glutamate enhances binding of GNE-8324 and vice versa. GNE-8324 selectively potentiates GluN2A subunit-containing NMDARs. As a consequence, GNE-8324 potentiation is highly dependent on glutamate site occupancy with enhanced GNE-8324 binding to glutamate-bound NMDARs compared to glutamate-free NMDARs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

343.42

Formula

C18H18FN3OS

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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GNE-8324
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HY-107498
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