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  3. GNE-886

GNE-886 (Compound 21) 是一种有效的选择性猫眼综合征染色体候选区 2 溴结构域抑制剂 (CECR2BRD),IC50 值为 0.016 µM,EC50 值为 370 nM。GNE-886 也抑制 BRD9IC50 值为 1.6 µM。

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GNE-886 Chemical Structure

GNE-886 Chemical Structure

CAS No. : 2101957-05-3

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生物活性

GNE-886 (Compound 21) is a potent and selective inhibitor of Cat eye syndrome chromosome region candidate 2 bromodomain (CECR2) (BRD) with an IC50 value of 0.016 µM and an EC50 value of 370 nM. GNE-886 also inhibits BRD9 with an IC50 value of 1.6 µM[1].

IC50 & Target

IC50: 0.016 µM (Cat eye syndrome chromosome region candidate 2 bromodomain, CECR2, BRD)[1]

分子量

498.58

Formula

C28H30N6O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

GNE-886 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GNE-886
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HY-117865
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