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Grossamide  (Synonyms: 克罗酰胺)

目录号: HY-N3979
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Grossamide 是一种能从 Cannabis sativa L. 的干果中分离出的天然产物。Grossamide 具有抗神经炎症作用。

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Grossamide Chemical Structure

Grossamide Chemical Structure

CAS No. : 80510-06-1

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Grossamide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Grossamide is a natural product that can be isolated from fructus cannabis, the dried fruit of Cannabis sativa L.. Grossamide has anti-neuroinflammatory effects[1].

体外研究
(In Vitro)

Grossamide downregulates LPS-mediated production of inflammatory molecules[1].
Grossamide (0-20 μM, 1 h) inhibits the mRNA levels of TNF-α and IL-6 in a dose-dependent manner, inhibits LPS-induced NF-κB activation, and inhibits LPS-induced TLR4 and MyD88 expression without cytotoxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Grossamide 相关抗体:

RT-PCR[1]

Cell Line: BV-2 microglia cell
Concentration: 0, 10, 15, and 20 μM
Incubation Time: 1 h and co-cultured with LPS (100 ng/mL) for another 6 h
Result: Inhibited the mRNA levels of TNF-α and IL-6 in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: BV-2 microglia cell
Concentration: 0, 10, 15, and 20 μM
Incubation Time: 1 h followed by LPS (100 ng/mL) stimulation for 1 h or 24 h
Result: Inhibited LPS-induced phosphorylation of IκBα and significantly reduced phosphorylation of NF-κB p65 levels. Dose-dependently decreased the expression of TLR4 and MyD88.

Cell Viability Assay[1]

Cell Line: BV-2 microglia cell
Concentration: 0, 10, 15, and 20 μM
Incubation Time: 1 h and co-cultured in the absence or presence of 100 ng/ mL LPS for 24 h
Result: Had no cytotoxicity.
分子量

624.68

Formula

C36H36N2O8
CAS 号
中文名称

克罗酰胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Grossamide 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Grossamide80510-06-1克罗酰胺OthersBV2 microglia cellsanti-neuroinflammatoryNF-κBTNF-αIL-6Inhibitorinhibitorinhibit

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