2. GPCR/G Protein
  3. Adenosine Receptor
  4. GW 328267

GW 328267 是一种 A2A 受体 激动剂。GW 328267 可用于哮喘、COPD 和上呼吸道炎症疾病的研究。

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GW 328267

GW 328267 Chemical Structure

CAS No. : 210237-78-8

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GW 328267 相关抗体

Top Publications Citing Use of Products

查看 Adenosine Receptor 亚型特异性产品:

查看所有亚型
Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW 328267 is an A2A receptor agonist. GW 328267 can be used for research of asthma, COPD and upper respiratory inflammatory disease[1].

IC50 & Target[1]

A2a adenosine receptor

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
4.2 nM
Compound: GW-328267
Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assay
Agonist activity at human adenosine A3 receptor expressed in CHO cells by GTPPgammaS binding assay
[PMID: 20031406]
CHO IC50
5 nM
Compound: 76
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as blockade of Cl-IB-MECA-mediated inhibition of forskolin-stimulated [3H]cAMP accumulation by scintillation counter
[PMID: 22468757]
CHO EC50
51 nM
Compound: GW-328267
Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay
Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as effect on cAMP production by luciferase reporter gene assay
[PMID: 20031406]
CHO EC50
882 nM
Compound: GW-328267
Agonist activity at human adenosine A1 receptor expressed in CHO cells by GTPPgammaS binding assay
Agonist activity at human adenosine A1 receptor expressed in CHO cells by GTPPgammaS binding assay
[PMID: 20031406]
PBMC IC50
1.3 nM
Compound: GW-328267
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA
Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA
[PMID: 20031406]
PBMC IC50
2.9 nM
Compound: GW-328267
Antiinflammatory activity in rat PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA
Antiinflammatory activity in rat PBMC assessed as inhibition of LPS-induced TNFalpha production after 20 hrs by ELISA
[PMID: 20031406]
分子量

482.50

Formula

C21H26N10O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GW 328267 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW 328267210237-78-8GW328267GW-328267Adenosine ReceptorP1 receptorInhibitorinhibitorinhibit

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产品名称：
GW 328267
目录号：
HY-108193
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