2. GPCR/G Protein Neuronal Signaling
  3. MCHR1 (GPR24)
  4. GW-803430

GW-803430  (Synonyms: GW-3430)

目录号: HY-11083 纯度: 99.10%
COA 产品使用指南

摩尔计算器

GW-803430 (GW-3430) 是一种有效的选择性黑色素浓缩激素受体 1 (MCH R1) 拮抗剂，pIC50 为 9.3。GW-803430 在肥胖动物模型中具有口服活性。

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GW-803430 Chemical Structure

GW-803430 Chemical Structure

CAS No. : 515141-51-2

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规格 价格 是否有货 数量
1 mg ￥2045
In-stock
5 mg ￥4500
In-stock
10 mg ￥7500
In-stock
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100 mg   询价  

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Customer Review

GW-803430 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC50 of 9.3. GW-803430 is orally active in an animal model of obesity[1].

IC50 & Target

pIC50: 9.3 (MCH R1)[1]
体外研究
(In Vitro)

GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC50 value of ~13 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GW-803430 相关抗体:
体内研究
(In Vivo)

GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls[1].
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High fat diet-induced obese AKR/J mice[1]
Dosage: 0.3, 3, and 15 mg/kg
Administration: Orally, qd,12 days
Result: Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.
分子量

481.99

Formula

C25H24ClN3O3S
CAS 号
性状

固体

颜色

Off-white to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.10%

COA (189 KB) HNMR (138 KB) RP-HPLC (168 KB) LCMS (107 KB)

产品使用指南 (1538 KB)
参考文献

GW-803430 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GW-803430515141-51-2GW-3430GW803430GW 803430GW3430GW 3430MCHR1 (GPR24)Melanin concentrating hormone receptor 1melaninobesityInhibitorinhibitorinhibit

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目录号：
HY-11083
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