2. Cytoskeleton
  3. Integrin
  4. huATN-658

huATN-658  (Synonyms: MNPR-101)

目录号: HY-P990552A 纯度: 99.67%
COA 技术支持

huATN-658 (MNPR-101) 是一种人源化单克隆抗体抑制剂，靶向尿激酶型纤溶酶原激活物受体(uPAR)。huATN-658 能够阻断 uPAR 与整合素之间的相互作用，抑制肿瘤细胞的增殖、侵袭和迁移。huATN-658 有望用于乳腺癌 (尤其是三阴性乳腺癌) 的研究。

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规格 价格 是否有货 数量
1 mg ￥3500
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Other Forms of huATN-658:

huATN-658 相关抗体

Top Publications Citing Use of Products

查看 Integrin 亚型特异性产品:

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

huATN-658 (MNPR-101) is a humanized monoclonal antibody inhibitor targeting urokinase-type plasminogen activator receptor (uPAR). huATN-658 blocks the interaction between uPAR and integrins, inhibiting the proliferation, invasion and migration of tumor cells. huATN-658 is promising for research of breast cancer (especially triple-negative breast cancer)[1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
IC50 & Target

PLAUR/uPAR/CD87
基因 ID

5329  [NCBI]

Accession
靶点

PLAUR/uPAR/CD87
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized huuPAR-Fc can bind huATN-658. The EC50 for this effect is 51.98 ng/mL.
纯度 & 产品资料
参考文献

huATN-658 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

huATN-658MNPR-101huATN658huATN 658MNPR101MNPR 101IntegrinuPARintegrinsbreast cancerInhibitorinhibitorinhibit

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