2. Anti-infection
  3. Bacterial
  4. Human Defensin-5 (1-9)

Human Defensin-5 (1-9) 是一种口服活性的抗菌肽。Human Defensin-5 (1-9) 可抑制西方饮食 (WSD) 或含果糖的西方饮食 (WSDF) 诱导的代谢紊乱。Human Defensin-5 (1-9) 通过上调回肠紧密连接蛋白和粘蛋白的基因表达，增强肠道屏障功能。Human Defensin-5 (1-9) 可用于肥胖及相关代谢疾病研究。

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Custom Peptide Synthesis

Human Defensin-5 (1-9)

Human Defensin-5 (1-9) Chemical Structure

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Human Defensin-5 (1-9) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Human Defensin-5 (1-9) is an orally active antimicrobial peptide. Human Defensin-5 (1-9) can inhibit metabolic disorders induced by Western-style diet (WSD) or Western-style diet with fructose (WSDF). Human Defensin-5 (1-9) enhances intestinal barrier function by upregulating the gene expression of ileal tight junction protein and mucins. Human Defensin-5 (1-9) can be used for the study of obesity and related metabolic diseases[1].

体内研究
(In Vivo)

Human Defensin-5 (1-9) (1.2 mg/kg，灌胃，每日一次，6 周) 减少雄性 C57BL/6J 小鼠在含果糖的西方饮食 (WSDF) 喂养下肝脏脂肪含量和肝脂滴数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice fed a Western-style diet with fructose (WSDF)[1]
Dosage: 1.2 mg/kg
Administration: i.g., once daily, 6 weeks
Result: Achieved liver fat reduction rates with statistical significance and hepatic lipid droplet reduction rates.
Showed a significant decrease in mesenteric fat cell area and a trend of reducing fat cell size.
Reduced blood glucose levels at 30 and 60 min post-glucose challenge and decreased glucose AUC.
Upregulated ileal ZO-1, Muc1 gene expression, showed a trend of upregulating Muc2 and reduced Lac/Man ratio.
Induced ileal Defa5, Lyz1, Reg3γand Wnt signaling molecules (Wnt3, Wnt5a, Wnt9a, Tcf1) gene expression.
分子量

1029.20

Formula

C40H68N16O12S2
Sequence

Ala-Thr-Cys-Tyr-Cys-Arg-Thr-Gly-Arg-NH2
Sequence Shortening

ATCYCRTGR-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Human Defensin-5 (1-9) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Human Defensin-5 (1-9)Bacterialantimicrobial peptideobesitymetabolic diseasesInhibitorinhibitorinhibit

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目录号：
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