2. Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. Phosphoglycerate Kinase (PGK) Fungal Apoptosis
  4. Ilicicolin H

Ilicicolin H 是一种选择性且非 ATP 竞争性的磷酸甘油酸激酶 1 (PGK1) (IC50 值为 9.02 μM) 和线粒体细胞色素 bc1 还原酶 (IC50 值为 2-3 ng/mL) 抑制剂。Ilicicolin H 直接与 PGK1 结合，KD 值为 60 μM。Ilicicolin H 能够抑制细胞增殖并诱导细胞凋亡 (apoptosis)。Ilicicolin H 可以抑制肝癌细胞的乳酸生成和葡萄糖摄取。Ilicicolin H 具有广泛的抗真菌谱，包括白色念珠菌 (C. albicans)、隐球菌属 (Cryptococcus) 和烟曲霉菌 (A. fumigatus)。licicolin H 可用于癌症和感染方面的研究，如肝细胞癌 (HCC) 和白色念珠菌感染。

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Ilicicolin H

Ilicicolin H Chemical Structure

CAS No. : 12689-26-8

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Ilicicolin H 相关抗体

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PGK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ilicicolin H is a selective and non-ATP-competitive phosphoglycerate kinase 1 (PGK1) (IC50 = 9.02 μM) and mitochondrial cytochrome bc1 reductase (IC50 = 2-3 ng/mL) inhibitor. Ilicicolin H directly binds to PGK1 with KD of 60 μM .Ilicicolin H can inhibit cell proliferation and induce apoptosis. Ilicicolin H can inhibit the lactate production and glucose uptake of hepatocellular carcinoma (HCC) cells. Ilicicolin H has a broad antifungal spectrum including C. albicans, Cryptococcus and A. fumigatus. Ilicicolin H can be used for the researches of cancer and infection, such as hepatocellular carcinoma (HCC) and C. albicans infection[1][2].

IC50 & Target[1]

PGK1

9.02 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
13.84 μM
Compound: 10
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
A549 IC50
7.01 μM
Compound: 10
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
B16-F10 IC50
21.58 μM
Compound: 10
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
CT26 IC50
19.54 μM
Compound: 10
Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse CT26 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
HCT-116 IC50
10.75 μM
Compound: 10
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
MC-38 IC50
19.55 μM
Compound: 10
Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against mouse MC38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
MDA-MB-231 IC50
9.98 μM
Compound: 10
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
MDA-MB-435 IC50
6.34 μM
Compound: 10
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-435 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
NCI-H1703 IC50
6.65 μM
Compound: 10
Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human NCI-H1703 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
PC-3 IC50
> 50 μM
Compound: 10
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
SNB-19 IC50
14.59 μM
Compound: 10
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human SNB-19 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
[PMID: 38527379]
体外研究
(In Vitro)

Ilicicolin H (1-8 μM, 24 h) 会诱导 HepG2 和 Huh7 细胞凋亡，并增加 Caspase-3、Caspase-9 的活性切割片段水平[1]。
Ilicicolin H (2-8 μM, 6 h) 会降低 CoCl 2 诱导的 HepG2 细胞中 HIF-1α 的水平，以及表皮生长因子诱导的该细胞中 PDHK1 在 T338 位点的磷酸化水平[1]。
Ilicicolin H (1-8 μM, 6 h) 会抑制 HepG2 细胞的乳酸生成和葡萄糖摄取[1]。
Ilicicolin H 对白色念珠菌 (C. albicans) 活性范围为 0.04 至 0.31 μg/mL、其他念珠菌属物种为 0.01 至 5.0 μg/mL、隐球菌属 (Cryptococcus) 的 MIC 值为 0.1-1.56 μg/mL，烟曲霉 (A. fumigatus) 的 MIC 值为 0.08 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ilicicolin H 相关抗体:

Apoptosis Analysis[1]

Cell Line: HepG2 and Huh7 cells
Concentration: 1, 2, 4 and 8 μM
Incubation Time: 24 h
Result: Increased C-Cas3, C-Cas9, and C-Parp levels.
Increased apoptotic cells.
体内研究
(In Vivo)

Ilicicolin H (6.25-50 mg/kg，口服，每日一次，连续 2 天) 可降低白色念珠菌 (C. albicans) 感染的小鼠模型中的白色念珠菌负荷量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C. albicans infected mice models[2]
Dosage: 6.25, 12.5, 25 and 50 mg/kg
Administration: Orally administration, daily for 2 days
Result: Reduced C. albicans burden.
分子量

433.54

Formula

C27H31NO4
CAS 号
结构分类
初始来源

Campylocarpon sp.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ilicicolin H 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ilicicolin H12689-26-8Phosphoglycerate Kinase (PGK)FungalApoptosisPhosphoglycerate KinasePGK1Bc1C. albicansCryptococcusHepG2Huh7Inhibitorinhibitorinhibit

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