2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK p38 MAPK
  4. ITZ-1

ITZ-1 是一种口服有效的、具有选择性的细胞外信号调节激酶 (ERK)-有丝分裂原活化蛋白激酶 (MAPK) 通路抑制剂，其抑制白细胞介素-1β (IL-1β) 诱导的基质金属蛋白酶-13 (MMP-13) 生成的 IC50 值为 0.51 μM。ITZ-1 可降低 MMP-13 的表达，并抑制一氧化氮 (NO) 诱导的软骨细胞凋亡。ITZ-1 有望用于骨关节疾病的研究。

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ITZ-1

ITZ-1 Chemical Structure

CAS No. : 1180532-17-5

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规格 是否有货
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ITZ-1 相关抗体

Top Publications Citing Use of Products

查看 ERK 亚型特异性产品:

查看所有亚型
ERK ERK1 ERK2 ERK5 ERK8

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases[1].

分子量

541.58

Formula

C20H20F5N3O3S3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ITZ-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITZ-11180532-17-5ITZ1ITZ 1ERKp38 MAPKExtracellular signal regulated kinasesMAPKosteoarticular diseasesInhibitorinhibitorinhibit

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