Jacaric acid 

Jacaric acid is a conjugated linolenic acid, which inhibits viability in cells PC-3 (IC₅₀ is 11.8 μM), LNCaP (IC₅₀ is 2.2 μM) and DLD-1, induces apoptosis and necrosis^[1]. Jacaric acid exhibits anticaner activity against prostate cancer and adenocarcinoma^[2]. Jacaric acid exhibits immunomodulating activity in murine peritoneal macrophages as an immunopotentiator^[3]. Jacaric acid is orally active.

Jacaric acid (0-10 μM) 剂量和时间依赖性地通过内在途径诱导 PC-细胞凋亡 (apoptosis)，通过内在途径和外在途径诱导 LNCaP 细胞凋亡 (apoptosis)^[1]。
Jacaric acid (0-10 μM) 通过细胞内掺入在 DLD-1 细胞内表达细胞毒性，并通过脂质过氧化诱导细胞凋亡 (apoptosis)^[2]。
Jacaric acid (50-100 μM) 通过分泌细胞因子 IFN-γ、IL-1β 和 TNF-α 来激活巨噬细胞，增强小鼠腹腔巨噬细胞的内吞活性，并对 MBL-2 细胞表达细胞抑制活性^{[3 ]}。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Jacaric acid (1 mg/day/mouse，口服 36 天) 在移植 DLD-1 的无胸腺裸鼠中表现出抗肿瘤活性，且无明显毒性^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

278.43

C₁₈H₃₀O₂

28872-28-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gasmi J, et al., Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. Phytomedicine. 2013 Jun 15;20(8-9):734-42..  [Content Brief]

  [2]. Shinohara N, et al., Jacaric acid, a linolenic acid isomer with a conjugated triene system, has a strong antitumor effect in vitro and in vivo. Biochim Biophys Acta. 2012 Jul;1821(7):980-8.  [Content Brief]

  [3]. Liu WN, et al., The Immunomodulatory Activity of Jacaric Acid, a Conjugated Linolenic Acid Isomer, on Murine Peritoneal Macrophages. PLoS One. 2015 Dec 2;10(12):e0143684.  [Content Brief]