2. Epigenetics Protein Tyrosine Kinase/RTK JAK/STAT Signaling Stem Cell/Wnt
  3. JAK
  4. JAK3-IN-12

JAK3-IN-12 (compound 5k) 是一种高效的 JAK3 抑制剂，对 JAK3、JAK1 和 JAK2 的 IC50 为 9.5 nM。JAK3-IN-12 可用于类风湿关节炎的研究。

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JAK3-IN-12 Chemical Structure

JAK3-IN-12 Chemical Structure

CAS No. : 1430095-86-5

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JAK3-IN-12 相关抗体

Top Publications Citing Use of Products

查看 JAK 亚型特异性产品:

查看所有亚型
JAK1 JAK2 JAK3 Tyk2 JAK

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].

IC50 & Target[1]

JAK3

9.5 nM (IC50)

JAK1

18 nM (IC50)

JAK2

42 nM (IC50)

体内研究
(In Vivo)

JAK3-IN-12 (compound 5k) shows moderate AUC, due to its high clearance, which resulted into overall low bioavailability[1].
Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1].

Tmax (h) Cmax (ng/ml) tmax (h) CL (mL/min/kg), iv AUC0-α (μg/mL·h) F (%)
IV (1 mg/kg);
PO (3 mg/kg)		 0.5 146±48 1.85±0.43 40.37 ± 3.61 192 ± 56 15

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice[1]
Dosage: 1 mg/kg for IV; 3 mg/kg for PO
Administration: IV or PO; single dosage
Result: Showed moderate AUC, due to its high clearance, which resulted into overall low bioavailability (15%).
分子量

413.45

Formula

C19H19N5O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JAK3-IN-12 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JAK3-IN-121430095-86-5JAKJanus kinaserheumatoid arthritisC57BL/6J miceInhibitorinhibitorinhibit

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