2. Neuronal Signaling
  3. Dopamine Transporter
  4. JJC8-088

JJC8-088 是一种 Modafinil- 衍生的配体，是一种多巴胺转运体 (DAT) 抑制剂，Ki 值为 2.53 nM。JJC8-088 用于研究精神刺激剂使用障碍。

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JJC8-088 Chemical Structure

JJC8-088 Chemical Structure

CAS No. : 1627576-82-2

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JJC8-088 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JJC8-088, a Modafinil-derived ligand, is a dopamine transporter (DAT) inhibitor with a Ki of 2.53 nM. JJC8-088 dioxalate can be to study psychostimulant use disorders[1][2].

IC50 & Target

DAT

2.53 nM (Ki)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK-293T IC50
> 10000 nM
Compound: 11b, JJC 8-088
Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 1
Antagonist activity at DRD2 (unknown origin) expressed in HEK293T cells transfected with Galphai1-RLuc8 and gamma2-GFP10 assessed as inhibition of quinpirole-induced Gi1 activation pre-incubated with quinpirole for 10 mins before compound incubation for 1
[PMID: 27933960]
体内研究
(In Vivo)

JJC8-088 (3-30 mg/kg, i.p., 30/120 min) 可有效减少大鼠的强迫性毒性分子的自我给药，并增加其运动量[1]。
JJC8-088 (0-30 mg/kg, i.p., 30 min prior to testing) 可引起毒性分子自我给药史大鼠的细胞外多巴胺 (DA) (HY-B0451) 水平的大量快速增加[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: METH addict male Wistar rats (6-8 weeks old; weighing 200-250 g)[1].
Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg
Administration: i.p.
Result: The half-life was 39 min.
Presented low levels in both brain and plasma.
分子量

498.63

Formula

C28H32F2N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JJC8-088 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JJC8-0881627576-82-2Dopamine TransporterDATSLC6A3hERGpsychostimulant use disordersPSUDInhibitorinhibitorinhibit

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产品名称：
JJC8-088
目录号：
HY-158013
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