2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. JNJ-26146900

JNJ-26146900 是一种具有口服活性的雄激素受体拮抗剂，对大鼠 AR 的 Ki 值为 400nM。JNJ-26146900 是一种非甾体雄激素受体 (AR) 配体。JNJ-26146900 可减小前列腺肿瘤并防止骨质流失。JNJ-26146900 可用于癌症研究。

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JNJ-26146900 Chemical Structure

JNJ-26146900 Chemical Structure

CAS No. : 868691-50-3

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JNJ-26146900 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-26146900 is a potent and orally active androgen receptor antagonist with a Ki value of 400nM for rat AR. JNJ-26146900 is a nonsteroidal androgen receptor (AR) ligand. JNJ-26146900 reduces prostate tumor size and prevents bone loss. JNJ-26146900 can be used in research of cancer[1].

体外研究
(In Vitro)

JNJ-26146900 与转染到 Cos-7 细胞中的大鼠雄激素受体结合，具有亚微摩尔效力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-26146900 相关抗体:
体内研究
(In Vivo)

JNJ-26146900 (10-100 mg/kg; p.o.; 成年雄性 Sprague-Dawley 大鼠) 同样有效地降低腹侧前列腺和肛提肌肌肉的湿重[1]。
JNJ-26146900 (30-100 mg/kg; p.o.) 在 Dunning 大鼠模型中防止前列腺肿瘤生长，在 10mg/kg 的剂量下最大限度地抑制生长。 JNJ-26146900 在 CWR22-LD1 小鼠人前列腺癌异种移植模型中显着抑制肿瘤生长[1]。
JNJ-26146900 (30 mg/kg; p.o.; 成年雄性 Sprague-Dawley 大鼠) 减少去势诱导的胫骨骨质流失[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mature male Sprague-Dawley rats[1]
Dosage: 10, 30, 100 mg/kg
Administration: oral gavage; daily, for 6 weeks
Result: Reduced ventral prostate weight.
Animal Model: CWR22-LD1 mouse xenograft model[1]
Dosage: 30, 100 mg/kg
Administration: oral gavage; twice per day for 3 weeks
Result: Inhibited tumor growth at 100 mg/kg, reducing mean tumor weight at Day 21 to about 30% of the intact vehicle tumor weight.
分子量

360.35

Formula

C15H15F3N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-26146900 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-26146900868691-50-3JNJ26146900JNJ 26146900Androgen Receptornonsteroidal androgen receptorprostate tumor sizebone lossInhibitorinhibitorinhibit

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目录号：
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