2. Anti-infection
  3. Parasite
  4. Koshidacin B

Koshidacin B 是抗疟原虫环四肽，对热带疟原虫 (P. falciparum) FCR3 和 K1 系抗疟原虫活性的 IC50 值分别为 0.89 和 0.83 μM。Koshidacin B 在体内抑制疟原虫，可用于疟原虫感染的研究。

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Koshidacin B Chemical Structure

Koshidacin B Chemical Structure

CAS No. : 2925302-01-6

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Koshidacin B 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection[1].

IC50 & Target

IC50: 0.89 μM (P. falciparum FCR3 strain), 0.83 μM (P. falciparum K1 strain), 14.7 μM (human MRC-5 cells)[1]
体外研究
(In Vitro)

Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC50 values of 0.89 and 0.83 μM, respectively[1].
Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC50 value of 14.7 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Koshidacin B 相关抗体:
体内研究
(In Vivo)

Koshidacin B (30 mg/kg; i.p.; once daily for 4 d) shows vivo antiplasmodial effects[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. berghei N strain-infected ICR (CD1) mice[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
Result: Suppressed 41% of malaria parasites.
分子量

544.64

Formula

C28H40N4O7
CAS 号
结构分类
初始来源

Pochonia boninensis
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Koshidacin B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Koshidacin B2925302-01-6Parasitecyclic tetrapeptideFCR3K1antiplasmodialMRC-5CD1malaria parasiteInhibitorinhibitorinhibit

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目录号：
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