1. Stem Cell/Wnt TGF-beta/Smad Epigenetics Anti-infection Apoptosis
  2. PKA PKC Bacterial Apoptosis Antibiotic
  3. KT5823

KT5823 是一种选择性 cGMP 依赖性蛋白激酶 (PKG) 抑制剂,Ki值为 0.23 μM,KT5823 也可以抑制 PKAPKCKi值分别为 10 μM 和 4 μM。 KT5823 是一种 staurosporine 星形孢菌素相关的蛋白激酶抑制剂,在甲状腺细胞中增加甲状腺刺激激素诱导的 (Na+/I- symporter) NIS 表达和碘离子摄取。 KT5823 引起细胞凋亡 (apoptotic) DNA 片段化水平的增加。

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KT5823 Chemical Structure

KT5823 Chemical Structure

CAS No. : 126643-37-6

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规格 价格 是否有货 数量
100 μg ¥2950
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  • 生物活性

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生物活性

KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an Ki value of 0.23 μM, it also inhibits PKA and PKC with Ki values of 10 μM and 4 μM, respectively[1]. KT5823 is a staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression, and iodide uptake in thyroid cells[2]. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation[3].

IC50 & Target[1]

PKA

10 μM (Ki)

PKC

4 μM (Ki)

分子量

495.53

Formula

C29H25N3O5

CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.68%

参考文献
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  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
KT5823
目录号:
HY-N6791
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