2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Immunology/Inflammation NF-κB Apoptosis Anti-infection
  3. Endogenous Metabolite CDK Reactive Oxygen Species Apoptosis Enterovirus Bacterial
  4. Lacto-N-fucopentaose I

Lacto-N-fucopentaose I  (Synonyms: LNFP I)

目录号: HY-W019806
COA 产品使用指南

摩尔计算器

Lacto-N-fucopentaose I (LNFPI) 是一种人母乳寡糖 (HMO)，具有抗病毒和抗菌活性。Lacto-N-fucopentaose I 通过减少衣壳蛋白 VP1 来阻断病毒吸附，增加 CDK2、减少 cyclin E 恢复细胞周期 S 期的阻滞。Lacto-N-fucopentaose I 抑制病毒感染的细胞凋亡 (apoptosis)。Lacto-N-fucopentaose I 也抑制 ROS 的产生。Lacto-N-fucopentaose I 还可以调节肠道菌群影响免疫系统发育。

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Lacto-N-fucopentaose I Chemical Structure

Lacto-N-fucopentaose I Chemical Structure

CAS No. : 7578-25-8

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1 mg ￥3795
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5 mg ￥8350
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Lacto-N-fucopentaose I 相关抗体

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lacto-N-fucopentaose I (LNFPI) is a human milk oligosaccharide (HMO), possessing antiviral and antibacterial activity. Lacto-N-fucopentaose I can reduce capsid protein VP1 to block virus adsorption, promote CDK2 and reduce cyclin E to recover cell cycle S phase block. Lacto-N-fucopentaose I inhibits ROS production and apoptosis in virus-infected cells. Lacto-N-fucopentaose I can also regulate intestinal microbiota to affect immune system development[1].

IC50 & Target

Human Endogenous Metabolite

 

CDK2/cyclinE

 

体外研究
(In Vitro)

Lacto-N-fucopentaose I (25-3200 μg/mL;48 h) exhibits certain cytotoxicity at 3200 μg/mL but no toxic reaction below 1600 μg/mL[1].
Lacto-N-fucopentaose I (25-1600 μg/mL; 14-18 h) can protect EV71-infected RD cells from death[1].
Lacto-N-fucopentaose I (100-400 μg/mL; 16 h) decreases markedly mRNA levels of VP1 and ROS production in EV71-infected RD cells at 400 μg/mL; leads to the recovery of EV71-induced S phase arrest in RD cells[1].
Lacto-N-fucopentaose I (100 and 200 μg/mL; 3 days) inhibits cell apoptosis in Caenorhabditis elegans; significantly decreases the levels of Egl-1, Ced-3 and Ced-4[1].
Lacto-N-fucopentaose I can reduce the abundance of Sphingobacterium, Stenotrophomonas and Achromobacter; can increase the abundance of Micromonospora, Vibrio, Acidibacter, Gaiella, Devosia, Steroidobacter, Variibacter, Dactylosporangium, RB41, Pir4_lineage, Pirellula, Haliangium, Roseiflexus, Pedomicrobium, and Bradyrhizobium.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lacto-N-fucopentaose I 相关抗体:

Cell Viability Assay[1]

Cell Line: RD cells
Concentration: 25, 50, 100, 200, 400, 800, 1600 and 3200 μg/mL
Incubation Time: 48 h
Result: Exhibited certain cytotoxicity at 3200 μg/mL but no toxic reaction below 1600 μg/mL.

RT-PCR[1]

Cell Line: RD cells (infected with EV71)
Concentration: 100, 200 and 400 μg/mL
Incubation Time: 16 h
Result: Decreased markedly mRNA levels of VP1 only at 400 μg/mL.

Apoptosis Analysis[1]

Cell Line: RD cells (infected with EV71)
Concentration: 100, 200 and 400 μg/mL
Incubation Time: 16 h
Result: Decreased the rate of cells in early apoptosis to 10.9% ± 1.26% at 400 μg/mL, while the untreated EV71 group was 27.7% ± 2.13%.
Significantly inhibited the activity of caspase-3, caspase-8 and caspase-9.
Recovered the decreased mRNA expression of PAPR, NF-κB and Bcl-2 and properly regulated Bad and Fas into their normal levels.

Cell Cycle Analysis[1]

Cell Line: RD cells (infected with EV71)
Concentration: 100, 200 and 400 μg/mL
Incubation Time: 12 h
Result: Rescued EV71-induced S phase arrest, which promoted the transition of the G1 phase to the S phase.
分子量

853.77

Formula

C32H55NO25
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源

human milk
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥90.0%

COA (278 KB)

产品使用指南 (1538 KB)
参考文献

Lacto-N-fucopentaose I 相关分类

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Keywords:

Lacto-N-fucopentaose I7578-25-8LNFP IEndogenous MetaboliteCDKReactive Oxygen SpeciesApoptosisEnterovirusBacterialCyclin dependent kinaseRhinovirusHRVHRVsHEVHEVsHMOVP1intestinal microbiotaRD cellsanti-inflammatoryInhibitorinhibitorinhibit

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