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  4. Levomepromazine hydrochloride

Levomepromazine hydrochloride  (Synonyms: Methotrimeprazine hydrochloride)

目录号: HY-B1693A
产品使用指南 技术支持

Levomepromazine (Methotrimeprazine) hydrochloride 是具有口服活性的抗精神疾病的化合物和 Ca2+ 释放诱导剂。Levomepromazine hydrochloride 可抑制 SERCA 泵并诱导细胞质 Ca2+ 水平增加。Levomepromazine hydrochloride 对多种神经递质受体 (neurotransmitter receptors) 具有拮抗作用，包括多巴胺能、胆碱能、血清素和组胺受体。Levomepromazine hydrochloride 能诱导适应性内质网应激和自噬 (autophagy)。此外，Levomepromazine hydrochloride 还具有抗病毒、抗炎、神经保护和镇痛、抗伤害的活性。Levomepromazine hydrochloride 可用于精神疾病以及缓解恶心和呕吐的研究。

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Levomepromazine hydrochloride

Levomepromazine hydrochloride Chemical Structure

CAS No. : 1236-99-3

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Levomepromazine hydrochloride 的其他形式现货产品:

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Other Forms of Levomepromazine hydrochloride:

Levomepromazine hydrochloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Levomepromazine (Methotrimeprazine) hydrochloride is an orally active antipsychotic compound and Ca2+ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca2+ levels. Levomepromazine hydrochloride has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine hydrochloride can induce adaptive ER stress and autophagy. In addition, Levomepromazine hydrochloride has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine hydrochloride can be used in the study psychiatric disorders and relieving nausea and vomiting[1][2][3][4].

体外研究
(In Vitro)

Levomepromazine (10 μM；24 小时) hydrochloride 可减少日本脑炎病毒 (JEV) 诱导的 Neuro2a 细胞死亡，降低 JEV RNA 水平和病毒滴度，以及显著抑制 JEV 蛋白翻译/复制复合物形成和 ROS 产生[1]。
Levomepromazine (10 μM；24 小时) hydrochloride 在小胶质细胞中通过诱导自噬降低细胞的炎症反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Levomepromazine hydrochloride 相关抗体:

Cell Viability Assay[1]

Cell Line: Japanese encephalitis virus treated Neuro2a
Concentration: 10 μM
Incubation Time: 24 h
Result: Reduced the level of JEV RNA.
体内研究
(In Vivo)

Levomepromazine (2 mg/kg；灌胃；15 天) hydrochloride 在日本脑炎病毒感染的小鼠模型中具有抗病毒和抗炎的活性[1]。
Levomepromazine (5-20 mg/kg；腹腔注射；单剂量) hydrochloride 在小鼠中具有镇痛、镇静和抗伤害的作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Japanese encephalitis virus-S3 infected C57BL/6 mouse[1]
Dosage: 2 mg/kg
Administration: Oral gavage (i.g.); 15 days
Result: Delayed virus invasion into the brain, and significantly lower viremia.
Showed complete protection of the barrier.
Reduced levels of multiple pro-inflammatory cytokines and interferon in the brains of infected mice.
分子量

364.93

Formula

C19H25ClN2OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Levomepromazine hydrochloride 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levomepromazine1236-99-3Methotrimeprazine5-HT ReceptorDopamine ReceptorHistamine ReceptorAutophagyEnterovirusCalcium ChannelSerotonin Receptor5-hydroxytryptamine ReceptorRhinovirusHRVHRVsHEVHEVsCa2+ channelsCa channelsschizophrenianeurolepticnauseavomitinghistaminedopaminergicInhibitorinhibitorinhibit

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