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  3. LY2140023

LY2140023 

目录号: HY-14554
产品使用指南

LY2140023 是一种口服有效的 LY404039 的前药。LY404039 是一种选择性的代谢型谷氨酸 2/3 受体激动剂。LY2140023 有用于精神分裂症的潜力。

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LY2140023 Chemical Structure

LY2140023 Chemical Structure

CAS No. : 635318-55-7

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Description

LY2140023 is an orally active prodrug of LY404039. LY404039 is a selective metabotropic glutamate 2/3 receptor agonist. LY2140023 has the potential for schizophrenia[1].

IC50 & Target[1]

mGluR2

 

mGluR3

 

In Vivo

LY2140023 (orally; 3, 10, and 300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[1].

Animal Model: Male Fischer rats (approximately 250 g)[1]
Dosage: 3, 10, and 300 mg/kg
Administration: Orally; once daily for 7 days
Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.
Clinical Trial
Molecular Weight

366.41

Formula

C₁₂H₁₈N₂O₇S₂

CAS No.

635318-55-7

SMILES

O=C([C@]1(NC([C@@H](N)CCSC)=O)CS([C@@]2([H])[C@H](C(O)=O)[C@@]12[H])(=O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

LY2140023LY 2140023LY-2140023mGluRMetabotropic glutamate receptorsorallyprodrugLY404039metabotropicglutamateschizophreniaInhibitorinhibitorinhibit

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产品名称:
LY2140023
目录号:
HY-14554
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