2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) 

目录号: HY-P11075
产品使用指南 技术支持

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) 是一种选择性 NK2R 激动剂，对 hNK2R 的 EC50 为 3.7 nM。[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) 显著抑制饮食诱导的肥胖 (DIO) 小鼠模型中的体重减轻，并改善野生型小鼠中 Loperamide (HY-156131) 诱导的排尿功能障碍。[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) 可用于神经激肽受体介导的疾病，例如肥胖、胰岛素抵抗和 2 型糖尿病研究。

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[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) Chemical Structure

CAS No. : 2770688-04-3

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[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) (ID 305) is a selective NK2R agonist with an EC50 of 3.7  nM for hNK2R. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) significantly inhibits weight loss in diet-induced obese (DIO) mice model and improves Loperamide (HY-156131)-induced dysfunctional voiding in wild-type mice. [Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) can be used for neurokinin receptor mediated disorders, such as obesity, insulin resistance and type 2 diabetes research[1].

IC50 & Target[1]

hNK2

3.7 nM (EC50)

hNK3

450-3500 nM (EC50)

分子量

819.99

Formula

C39H65N9O10
CAS 号
Sequence

Asp-Lys-Tyr-Val-Gly-{Leu(NMe)}-{Nle}-NH2
Sequence Shortening

DKYVG-{Leu(NMe)}-{Nle}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Lys5,Tyr6,mLeu9,Nle10]-Neurokinin A (4-10)2770688-04-3Neurokinin ReceptorNK receptorTachykinin receptorAgonistNK2RDIO mice modelObesityInsulin resistanceType 2 diabetesInhibitorinhibitorinhibit

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