1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. MBCQ

MBCQ 

目录号: HY-114672
产品使用指南

MBCQ 是一种有效的选择性 V 型磷酸二酯酶 (PDE V; PDE5) 抑制剂,IC50 为 19 nM。MBCQ 对 PDE1,PDE2,PDE3 和 PDE4 的 IC50 均大于 100 µM。MBCQ 通过有效和特异性抑制 cGMP-PDE 来扩张冠状动脉。

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MBCQ Chemical Structure

MBCQ Chemical Structure

CAS No. : 150450-53-6

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10 mg ¥1500 Ask For Quote & Lead Time
25 mg ¥3000 Ask For Quote & Lead Time
50 mg ¥5000 Ask For Quote & Lead Time

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Description

MBCQ is a potent and selective the type V phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ has IC50s >100 µM for PDE1, PDE2, PDE3, and PDE4, respectively. MBCQ dilates coronary arteries via potent and specific inhibition of cGMP-PDE[1][2][3].

IC50 & Target[1]

PDE V

19 nM (IC50)

PDE Ⅰ

>100 μM (IC50)

PDE Ⅱ

>100 μM (IC50)

PDE Ⅲ

>100 μM (IC50)

PDE Ⅳ

>100 μM (IC50)

In Vitro

MBCQ (compound 3d) induces relaxation of isolated porcine coronary arteries precontracted with prostaglandin F2α (PGF2α; EC50=190 nM)[1].
MBCQ (0.01-10 μM; 10 min) inhibits Carbachol (10 μM)-induced contractions in a concentration-dependent manner in rat ileal smooth muscle[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

313.74

Formula

C₁₆H₁₂ClN₃O₂

CAS No.

150450-53-6

SMILES

ClC1=CC2=C(N=CN=C2NCC3=CC4=C(C=C3)OCO4)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

MBCQPhosphodiesterase (PDE)coronaryarteriescGMP-PDEPGF2αInhibitorinhibitorinhibit

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产品名称:
MBCQ
目录号:
HY-114672
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