2. Academic Validation
  3. The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy

The SGLT2 Inhibitor Canagliflozin Reduces Atherosclerosis by Enhancing Macrophage Autophagy

  • J Cardiovasc Transl Res. 2023 May 1. doi: 10.1007/s12265-023-10390-w.
Hongping Chen # 1 2,  Da Teng # 1 2,  Bowen Xu # 3,  Chunxiao Wang 2,  Hua Wang 2,  Wenjuan Jia 2,  Lei Gong 2,  Haibin Dong 2,  Lin Zhong 4,  Jun Yang 5
Affiliations

Affiliations

  • 1 School of Medicine, Qingdao University, Qingdao, China.
  • 2 Department of Cardiology, Yuhuangding Hospital, The Fourth School of Clinical Medicine of Qingdao University, Yantai, Shandong Province, China.
  • 3 Binzhou Medical University, Yantai, Shandong Province, China.
  • 4 Department of Cardiology, Yuhuangding Hospital, The Fourth School of Clinical Medicine of Qingdao University, Yantai, Shandong Province, China. yizun1971@126.com.
  • 5 Department of Cardiology, Yuhuangding Hospital, The Fourth School of Clinical Medicine of Qingdao University, Yantai, Shandong Province, China. yangjyhd@163.com.
  • # Contributed equally.
PMID: 37126209 DOI: 10.1007/s12265-023-10390-w
Abstract

It has been shown that SGLT2 suppresses atherosclerosis (AS). Recent studies indicate that Autophagy widely participates in atherogenesis. This study aimed to assess the effect of canagliflozin (CAN) on atherogenesis via Autophagy. Macrophages and ApoE - / - mice were used in this study. In macrophages, the results showed that CAN promoted LC3II expression and autophagosome formation. Furthermore, the Cholesterol efflux assay demonstrated that CAN enhanced Cholesterol efflux from macrophages via Autophagy, resulting in lower lipid droplet concentrations in macrophages. The western blot revealed that CAN regulated Autophagy via the AMPK/ULK1/Beclin1 signaling pathway. CAN resulted in increased macrophage Autophagy in atherosclerotic plaques of ApoE - / - mice, confirming that CAN could inhibit the progression of AS via promoting macrophage Autophagy. The current study found that CAN reduced the production of atherosclerotic lesions, which adds to our understanding of how SGLT2 inhibitors function to delay the progression of AS.

Keywords

Atherosclerosis; Autophagy; Macrophage; SGLT2 inhibitor.

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