2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK
  4. MK-8353 hydrochloride

MK-8353 hydrochloride  (Synonyms: SCH900353 hydrochloride; MK-8353-001)

目录号: HY-111407A
产品使用指南 技术支持

MK-8353 (SCH900353) hydrochloride 是一种有效的，选择性的，口服活性的 ERK1/2 抑制剂，IC50 值分别为 23.0 nM 和 8.8 nM。MK-8353 具有抗肿瘤活性。

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MK-8353 hydrochloride

MK-8353 hydrochloride Chemical Structure

CAS No. : 1951448-73-9

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MK-8353 hydrochloride 的其他形式现货产品:

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Other Forms of MK-8353 hydrochloride:

MK-8353 hydrochloride 相关抗体

Top Publications Citing Use of Products

    MK-8353 hydrochloride purchased from MCE. Usage Cited in: Mol Med Rep. 2023 Feb;27(2):30.  [Abstract]

    MK‑8353 partially counteractes the inhibitory effects of S100A1 overexpression on Nrf2 level in PC12 cells.

    查看 ERK 亚型特异性产品:

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    ERK ERK1 ERK2 ERK5 ERK8

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    MK-8353 (SCH900353) hydrochloride is a potent, selective, orally active ERK1/2 inhibitor with IC50 values of 23.0 nM and 8.8 nM, respectively. MK-8353 exhibits antitumor activity[1].

    IC50 & Target[1]

    ERK1

    23 nM (IC50)

    ERK2

    8.8 nM (IC50)

    分子量

    728.31

    Formula

    C37H42ClN9O3S
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    MK-8353 hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    MK-83531951448-73-9SCH900353 MK-8353-001MK8353MK 8353SCH 900353SCH-900353ERKExtracellular signal regulated kinasesantitumorInhibitorinhibitorinhibit

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