1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. ML-60218

ML-60218 

目录号: HY-122122 纯度: >99.0%
产品使用指南

ML-60218 是一种广谱 RNA pol III 抑制剂,对酿酒酵母和人类 RNA pol III 的 IC50 分别为 32 和 27 μM。ML-60218 破坏已经组装好的病毒体,并且在不需要重新转录细胞 RNA 的情况下阻碍新病毒体的形成。

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ML-60218 Chemical Structure

ML-60218 Chemical Structure

CAS No. : 577784-91-9

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Description

ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2].

In Vitro

Combination of SAHA and ML-60218 produces enhanced suppression of proliferation in human pancreatic adenocarcinoma by impairing cell cycle progression and inducing apoptosis. ML-60218 reverses SAHA-stimulated tRNA expression in PANC-1 and BxPC-3 cells. ML-60218 enhances the ability of HDAC inhibitors to induce apoptosis and cell cycle arrest[2].
In in vitro transcription assays with purified double-layered particles (DLPs), ML-60218 shows dose-dependent inhibitory activity, indicating the viral nature of its target. ML-60218 is found to interfere with the formation of higher-order structures of VP6, the protein forming the DLP outer layer, without compromising its ability to trimerize. Electron microscopy of ML-60218-treated DLPs shows dose-dependent structural damage. ML-60218-mediated (10 μM ) viroplasm disruption causes NSP5 dephosphorylation[3].

Molecular Weight

452.38

Formula

C₁₉H₁₅Cl₂N₃O₂S₂

CAS No.

577784-91-9

SMILES

O=S(C1=CC=CC=C1Cl)(NC2=CC(C3=C(C)C4=CC(Cl)=CC=C4S3)=NN2C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-80°C

References

Purity: >99.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

ML-60218ML60218ML 60218DNA/RNA Synthesisbroad-spectrumyeastviroplasmstranscriptionInhibitorinhibitorinhibit

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产品名称:
ML-60218
目录号:
HY-122122
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