1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML133 hydrochloride

ML133 hydrochloride 

目录号: HY-100230A 纯度: 99.89%
产品使用指南

ML133 (hydrochloride) 是一个选择性的 Kir2 家族通道的抑制剂,在pH 7.4 和pH 8.5 时的 IC50 值分别为1.8 μM 和290 nM。

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ML133 hydrochloride Chemical Structure

ML133 hydrochloride Chemical Structure

CAS No. : 1222781-70-5

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     可免费申领三个不同产品的试用装。

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥550 In-stock
5 mg ¥500 In-stock
10 mg ¥700 In-stock
50 mg ¥2100 In-stock
100 mg ¥3500 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

ML133 (hydrochloride) is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5[1].

IC50 & Target

IC50: 1.8 μM (Kir2 at pH 7.4), 290 nM (Kir2 at pH 8.5)[1].

Molecular Weight

313.82

Formula

C₁₉H₂₀ClNO

CAS No.

1222781-70-5

SMILES

COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (398.32 mM)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1865 mL 15.9327 mL 31.8654 mL
5 mM 0.6373 mL 3.1865 mL 6.3731 mL
10 mM 0.3187 mL 1.5933 mL 3.1865 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.63 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
ML133 hydrochloride
目录号:
HY-100230A
需求量:

ML133 hydrochloride

Cat. No.: HY-100230A