1. Metabolic Enzyme/Protease
  2. Proteasome
  3. ML604440

ML604440 

目录号: HY-114170
产品使用指南

ML604440 是一种有效的,特异性和细胞可渗透的蛋白酶体 β1i (LMP2) 亚基抑制剂。 ML604440 破坏 MHC I 类细胞表面表达,IL-6 分泌以及 naïve T helper 向 17 T helper 细胞的分化。ML604440 改善实验性结肠炎和 EAE 疾病。

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ML604440 Chemical Structure

ML604440 Chemical Structure

CAS No. : 1140517-08-3

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Description

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor[1]. ML604440 impairs MHC class I cell surface expression, IL-6 secretion and differentiation of naïve T helper cells to T helper 17 cells. ML604440 strongly ameliorates disease in experimental colitis and EAE[2].

IC50 & Target

proteasome β1i (LMP2) subunit inhibitor[1]

Molecular Weight

388.19

Formula

C₁₇H₂₄BF₃N₂O₄

CAS No.

1140517-08-3

SMILES

CC(C)C[C@@H](B(O)O)NC(C(NC(C1=CC=CC=C1C(F)(F)F)=O)(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
ML604440
目录号:
HY-114170
需求量:

ML604440

Cat. No.: HY-114170