1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. MSRV-IN-1

MSRV-IN-1 (Compound M3) 是一种针对水生弹状病毒 (如 MSRVSVCVIHNV) 的抑制剂,其抑制 MSRVSVCVIHNVIC50 分别为 0.92 μM、2.92 μM 和 2.78 μM。MSRV-IN-1 并非直接作用于病毒粒子,而是通过改变病毒诱导的细胞周期 S 期阻滞状态,破坏病毒复制环境,进而抑制病毒复制。以 20 mg/kg 剂量腹腔注射,MSRV-IN-1 可使感染 MSRV 的大口黑鲈存活率显著提升 35.98%,并降低肝、脾、肾中的病毒载量。MSRV-IN-1 可用于水产养殖中弹状病毒相关疾病领域的研究。

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MSRV-IN-1 Chemical Structure

MSRV-IN-1 Chemical Structure

CAS No. : 1438403-50-9

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  • 生物活性

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生物活性

MSRV-IN-1 (Compound M3) is an inhibitor targeting aquatic rhabdoviruses (such as MSRV, SVCV and IHNV). Its IC50 values for inhibiting MSRV, SVCV and IHNV are 0.92 μM, 2.92 μM and 2.78 μM respectively. MSRV-IN-1 does not act directly on the virions but rather inhibits viral replication by altering the cell cycle arrest state in the S phase induced by the virus and disrupting the viral replication environment. When administered intraperitoneally at a dose of 20 mg/kg, MSRV-IN-1 can significantly increase the survival rate of largemouth bass infected with MSRV by 35.98% and reduce the viral loads in the liver, spleen and kidney. MSRV-IN-1 can be used in the research of diseases related to rhabdoviruses in aquaculture[1].

分子量

356.33

Formula

C18H16N2O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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产品名称:
MSRV-IN-1
目录号:
HY-173338
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