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N,N'-Dimethylthiourea (Synonyms: N,N-二甲基硫脲; DMTU)

目录号: HY-W027951
产品使用指南

N,N'-Dimethylthiourea (DMTU) 是从黑蒜中分离出来的,是口服有效的羟基自由基 (•OH) 的清除剂,通过活化的中性粒细胞在体外阻止 •OH 的产生。N,N'-Dimethylthiourea 通过发挥抗氧化作用,包括 •OH 清除和抗炎作用,防止水浸限制应激 (WIRS) 诱导的大鼠胃粘膜损伤。

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N,N'-Dimethylthiourea Chemical Structure

N,N'-Dimethylthiourea Chemical Structure

CAS No. : 534-13-4

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Description

N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2].

In Vivo

N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

104.17

Formula

C₃H₈N₂S

CAS No.

534-13-4

中文名称

N,N-二甲基硫脲

SMILES

S=C(NC)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
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Keywords:

N,N'-DimethylthioureaDMTUOthersorallyOHWIRSscavenginInhibitorinhibitorinhibit

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N,N'-Dimethylthiourea
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