1. Apoptosis
    PROTAC
  2. Bcl-2 Family
    Ligand for Target Protein for PROTAC
  3. Navitoclax-piperazine

Navitoclax-piperazine (Synonyms: ABT-263-piperazine)

目录号: HY-44432
产品使用指南

Navitoclax-piperazine (ABT-263-piperazine) 是一种特大型 B 细胞淋巴瘤 (BCL-XL) 抑制剂。Navitoclax-piperazine 和 E3 泛素连接酶的 VHL 配体可用来合成 PROTAC DT2216 (HY-130604)。

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Navitoclax-piperazine Chemical Structure

Navitoclax-piperazine Chemical Structure

CAS No. : 2143096-93-7

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Description

Navitoclax-piperazine (ABT-263-piperazine) is a B-cell lymphoma extra large (BCL-XL) inhibitor. Navitoclax-piperazine and a VHL ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC DT2216 (HY-130604)[1].

IC50 & Target

Bcl-xL

 

Molecular Weight

973.63

Formula

C₄₇H₅₆ClF₃N₆O₅S₃

CAS No.

2143096-93-7

SMILES

O=C(NS(=O)(C1=CC=C(N[C@@H](CSC2=CC=CC=C2)CCN3CCNCC3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CCC(C)(C)C6)CC5)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Navitoclax-piperazineABT-263-piperazineBcl-2 FamilyLigand for Target Protein for PROTACTarget Protein-binding MoietyB-celllymphomaVHLE3ubiquitinligaseInhibitorinhibitorinhibit

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产品名称:
Navitoclax-piperazine
目录号:
HY-44432
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